2-(4-(4-fluorophenyl)-3-iodo-2,8-dioxo-1-azaspiro[4.5]deca-3,6,9-trien-1-yl)acetaldehyde

Base Information

• Chemical Name: 2-(4-(4-fluorophenyl)-3-iodo-2,8-dioxo-1-azaspiro[4.5]deca-3,6,9-trien-1-yl)acetaldehyde
• CAS No.: 1383128-84-4
• Molecular Formula: C₁₇H₁₁FINO₃
• Molecular Weight: 423.182
• Mol file: 1383128-84-4.mol

Synonyms:2-(4-(4-fluorophenyl)-3-iodo-2,8-dioxo-1-azaspiro[4.5]deca-3,6,9-trien-1-yl)acetaldehyde

Chemical Property of 2-(4-(4-fluorophenyl)-3-iodo-2,8-dioxo-1-azaspiro[4.5]deca-3,6,9-trien-1-yl)acetaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-(4-fluorophenyl)-3-iodo-2,8-dioxo-1-azaspiro[4.5]deca-3,6,9-trien-1-yl)acetaldehyde

There total 1 articles about 2-(4-(4-fluorophenyl)-3-iodo-2,8-dioxo-1-azaspiro[4.5]deca-3,6,9-trien-1-yl)acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-(2,2-diethoxyethyl)-4-(4-fluorophenyl)-3-iodo-1-azaspiro[4.5]deca-3,6,9-triene-2,8-dione (1383129-65-4) → 2-(4-(4-fluorophenyl)-3-iodo-2,8-dioxo-1-azaspiro[4.5]deca-3,6,9-trien-1-yl)acetaldehyde (1383128-84-4)

Guidance literature:

With iodine; In acetone; at 20 ℃; Inert atmosphere;

DOI:10.1039/c2cc32783j

Reference yield:

2-(4-(4-fluorophenyl)-3-iodo-2,8-dioxo-1-azaspiro[4.5]deca-3,6,9-trien-1-yl)acetaldehyde (1383128-84-4) → C17H11FINO3 + (6aS,10aR)-1-(4-fluorophenyl)-2-iodo-6a,7-dihydropyrrolo[2,1-i]indole-3,6,8(5H)-trione (1383129-05-2)

Guidance literature:

With (5aS,6R,9S,9aR)-6,11,11-trimethyl-2-phenyl-5a,6,7,8,9,9a-hexahydro-4H-6,9-methano-benzo[b][1,2,4]triazolo[4,3-d][1,4]oxazin-2-ium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In toluene; at 25 ℃; for 90h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1039/c2cc32783j

upstream raw materials:

1-(2,2-diethoxyethyl)-4-(4-fluorophenyl)-3-iodo-1-azaspiro[4.5]deca-3,6,9-triene-2,8-dione

Downstream raw materials:

(6aS,10aR)-1-(4-fluorophenyl)-2-iodo-6a,7-dihydropyrrolo[2,1-i]indole-3,6,8(5H)-trione