(S,E)-1-(3-cyclohexyl-3-oxo-prop-1-en-1-yl)-2-oxo-cyclopentanecarboxylic acid tert-butyl ester

Base Information

• Chemical Name: (S,E)-1-(3-cyclohexyl-3-oxo-prop-1-en-1-yl)-2-oxo-cyclopentanecarboxylic acid tert-butyl ester
• CAS No.: 1158184-22-5
• Molecular Formula: C₁₉H₂₈O₄
• Molecular Weight: 320.429
• Mol file: 1158184-22-5.mol

Synonyms:(S,E)-1-(3-cyclohexyl-3-oxo-prop-1-en-1-yl)-2-oxo-cyclopentanecarboxylic acid tert-butyl ester

Chemical Property of (S,E)-1-(3-cyclohexyl-3-oxo-prop-1-en-1-yl)-2-oxo-cyclopentanecarboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S,E)-1-(3-cyclohexyl-3-oxo-prop-1-en-1-yl)-2-oxo-cyclopentanecarboxylic acid tert-butyl ester

There total 2 articles about (S,E)-1-(3-cyclohexyl-3-oxo-prop-1-en-1-yl)-2-oxo-cyclopentanecarboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1-cyclohexyl-2-propyn-1-one (7560-69-2) + tert-butyl 2-oxocyclopentanecarboxylate (84109-76-2) → (S,E)-1-(3-cyclohexyl-3-oxo-prop-1-en-1-yl)-2-oxo-cyclopentanecarboxylic acid tert-butyl ester (1158184-22-5)

Guidance literature:

1-cyclohexyl-2-propyn-1-one; tert-butyl 2-oxocyclopentanecarboxylate; With C₃₈H₃₀Co₂N₂O₁₀; at 24 - 28 ℃; for 4h;

With diphenyl(methyl)phosphine; at 24 - 28 ℃; for 4h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1002/anie.200805967

Reference yield:

1-cyclohexyl-2-propyn-1-one (7560-69-2) + tert-butyl 2-oxocyclopentanecarboxylate (84109-76-2) → (S,E)-1-(3-cyclohexyl-3-oxo-prop-1-en-1-yl)-2-oxo-cyclopentanecarboxylic acid tert-butyl ester (1158184-22-5) + C19H28O4 + C19H28O4

Guidance literature:

With Br^(1-)*C₇₆H₄₅F₂₄N₂⁽¹⁺⁾; potassium carbonate; In diethyl ether; at -40 ℃; for 2h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1021/op100014v

upstream raw materials:

1-cyclohexyl-2-propyn-1-one

tert-butyl 2-oxocyclopentanecarboxylate