trans-4-(2',2'-dimethoxyethyl)-3-(1'-o-nitrobenzyloxycarbonyloxyethyl)-2-azetidinone

Base Information

Chemical Name:trans-4-(2',2'-dimethoxyethyl)-3-(1'-o-nitrobenzyloxycarbonyloxyethyl)-2-azetidinone
CAS No.:72679-64-2
Molecular Formula:C₁₇H₂₂N₂O₈
Molecular Weight:382.37
Hs Code.:

Synonyms:trans-4-(2',2'-dimethoxyethyl)-3-(1'-o-nitrobenzyloxycarbonyloxyethyl)-2-azetidinone

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Chemical Property of trans-4-(2',2'-dimethoxyethyl)-3-(1'-o-nitrobenzyloxycarbonyloxyethyl)-2-azetidinone

Chemical Property:

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Technology Process of trans-4-(2',2'-dimethoxyethyl)-3-(1'-o-nitrobenzyloxycarbonyloxyethyl)-2-azetidinone

There total 1 articles about trans-4-(2',2'-dimethoxyethyl)-3-(1'-o-nitrobenzyloxycarbonyloxyethyl)-2-azetidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 72679-64-2
Carbonic acid 1-[(2R,3S)-2-(2,2-dimethoxy-ethyl)-4-oxo-azetidin-3-yl]-ethyl ester 2-nitro-benzyl ester

Guidance literature:: Azetidinon 4, o-Nitrobenzylchlorformat in Ggw. von N,N-Dimethylaminopyridin;

Reference yield:

: 72679-64-2
trans-4-(2',2'-dimethoxyethyl)-3-(1'-o-nitrobenzyloxycarbonyloxyethyl)-2-azetidinone

: 69060-98-6,72746-73-7,73890-32-1,78342-08-2,84366-99-4,84367-00-0
o-nitrobenzyl 6-((8S*)-o-nitrobenzyloxycarbonyloxyethyl)-1-carba-2-penem-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 69 percent / molecular sieves / dimethylformamide; toluene / 24 h / Ambient temperature

2: SO₂Cl₂, 2,6-lutidine / tetrahydrofuran / 0.5 h / -20 °C

3: 74 percent / 2,6-lutidine / dioxane / Ambient temperature

4: 55.4 percent / p-toluenesulfonic acid / acetone / 2 h / Ambient temperature

With 2,6-dimethylpyridine; sulfuryl dichloride; molecular sieve; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1021/ja00526a048

Reference yield:

: 72679-64-2
trans-4-(2',2'-dimethoxyethyl)-3-(1'-o-nitrobenzyloxycarbonyloxyethyl)-2-azetidinone

: Chloro-{(2R,3S)-2-(2,2-dimethoxy-ethyl)-3-[(S)-1-(2-nitro-benzyloxycarbonyloxy)-ethyl]-4-oxo-azetidin-1-yl}-acetic acid 2-nitro-benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / molecular sieves / dimethylformamide; toluene / 24 h / Ambient temperature

2: SO₂Cl₂, 2,6-lutidine / tetrahydrofuran / 0.5 h / -20 °C

With 2,6-dimethylpyridine; sulfuryl dichloride; molecular sieve; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ja00526a048