methyl 7-chloro-5-(2-chlorophenyl)-1-neopentyl-2-oxo-1,2,4,5-tetrahydro-3H-1,3-benzodiazepine-3-acetate

Base Information

Chemical Name:methyl 7-chloro-5-(2-chlorophenyl)-1-neopentyl-2-oxo-1,2,4,5-tetrahydro-3H-1,3-benzodiazepine-3-acetate
CAS No.:165953-10-6
Molecular Formula:C₂₃H₂₆Cl₂N₂O₃
Molecular Weight:449.377
Hs Code.:

Synonyms:methyl 7-chloro-5-(2-chlorophenyl)-1-neopentyl-2-oxo-1,2,4,5-tetrahydro-3H-1,3-benzodiazepine-3-acetate

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Chemical Property of methyl 7-chloro-5-(2-chlorophenyl)-1-neopentyl-2-oxo-1,2,4,5-tetrahydro-3H-1,3-benzodiazepine-3-acetate

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Technology Process of methyl 7-chloro-5-(2-chlorophenyl)-1-neopentyl-2-oxo-1,2,4,5-tetrahydro-3H-1,3-benzodiazepine-3-acetate

There total 10 articles about methyl 7-chloro-5-(2-chlorophenyl)-1-neopentyl-2-oxo-1,2,4,5-tetrahydro-3H-1,3-benzodiazepine-3-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 32315-10-9
bis(trichloromethyl) carbonate

: 165952-45-4
methyl N-[2-(5-chloro-2-neopentylaminophenyl)-2-(2-chlorophenyl)ethyl]glycinate

: 165953-10-6
methyl 7-chloro-5-(2-chlorophenyl)-1-neopentyl-2-oxo-1,2,4,5-tetrahydro-3H-1,3-benzodiazepine-3-acetate

Guidance literature:: With triethylamine; In toluene; at 70 ℃; for 5h;
DOI:10.1016/S0968-0896(01)00289-9

Reference yield:

: 57486-68-7
methyl (2-chlorophenyl)acetate

: 165953-10-6
methyl 7-chloro-5-(2-chlorophenyl)-1-neopentyl-2-oxo-1,2,4,5-tetrahydro-3H-1,3-benzodiazepine-3-acetate

Guidance literature:: Multi-step reaction with 9 steps

1.1: 58 percent / NaH / dimethylformamide / 1 h / 0 °C

2.1: 46 percent / LiBH₄ / tetrahydrofuran / 4 h / 20 °C

3.1: 83 percent / DMSO; oxalyl chloride; NEt₃ / CH₂Cl₂ / -78 - 0 °C

4.1: NaOAc / methanol / 0.5 h / 20 °C

4.2: 52 percent / NaBH₃CN / methanol / 3 h / 50 °C

5.1: 96 percent / pyridine / CH₂Cl₂ / 0.17 h / 20 °C

6.1: 42 percent / H₂ / 10 percent Pd-C / ethyl acetate / 8 h / 20 °C

7.1: AcOH / methanol / 0.5 h / 20 °C

7.2: 60 percent / NaBH₃CN / methanol / 1 h / 20 °C

8.1: 44 percent / conc. HCl / methanol / Heating

9.1: 60 percent / NEt₃ / toluene / 5 h / 70 °C

With pyridine; hydrogenchloride; lithium borohydride; oxalyl dichloride; hydrogen; sodium acetate; sodium hydride; acetic acid; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; 3.1: Swern oxidation;
DOI:10.1016/S0968-0896(01)00289-9

Reference yield:

: 610-40-2
3,4-dinitro-chlorobenzene

: 165953-10-6
methyl 7-chloro-5-(2-chlorophenyl)-1-neopentyl-2-oxo-1,2,4,5-tetrahydro-3H-1,3-benzodiazepine-3-acetate

Guidance literature:: Multi-step reaction with 9 steps

1.1: 58 percent / NaH / dimethylformamide / 1 h / 0 °C

2.1: 46 percent / LiBH₄ / tetrahydrofuran / 4 h / 20 °C

3.1: 83 percent / DMSO; oxalyl chloride; NEt₃ / CH₂Cl₂ / -78 - 0 °C

4.1: NaOAc / methanol / 0.5 h / 20 °C

4.2: 52 percent / NaBH₃CN / methanol / 3 h / 50 °C

5.1: 96 percent / pyridine / CH₂Cl₂ / 0.17 h / 20 °C

6.1: 42 percent / H₂ / 10 percent Pd-C / ethyl acetate / 8 h / 20 °C

7.1: AcOH / methanol / 0.5 h / 20 °C

7.2: 60 percent / NaBH₃CN / methanol / 1 h / 20 °C

8.1: 44 percent / conc. HCl / methanol / Heating

9.1: 60 percent / NEt₃ / toluene / 5 h / 70 °C

With pyridine; hydrogenchloride; lithium borohydride; oxalyl dichloride; hydrogen; sodium acetate; sodium hydride; acetic acid; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; 3.1: Swern oxidation;
DOI:10.1016/S0968-0896(01)00289-9