3-{4-[1-(4-cyclohex-1-enyl-phenyl)-3-(3,5-dichloro-phenyl)-ureidomethyl]-benzoylamino}-propionic acid methyl ester

Base Information

Chemical Name:3-{4-[1-(4-cyclohex-1-enyl-phenyl)-3-(3,5-dichloro-phenyl)-ureidomethyl]-benzoylamino}-propionic acid methyl ester
CAS No.:1056595-21-1
Molecular Formula:C₃₁H₃₁Cl₂N₃O₄
Molecular Weight:580.511
Hs Code.:

Synonyms:3-{4-[1-(4-cyclohex-1-enyl-phenyl)-3-(3,5-dichloro-phenyl)-ureidomethyl]-benzoylamino}-propionic acid methyl ester

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Chemical Property of 3-{4-[1-(4-cyclohex-1-enyl-phenyl)-3-(3,5-dichloro-phenyl)-ureidomethyl]-benzoylamino}-propionic acid methyl ester

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Technology Process of 3-{4-[1-(4-cyclohex-1-enyl-phenyl)-3-(3,5-dichloro-phenyl)-ureidomethyl]-benzoylamino}-propionic acid methyl ester

There total 6 articles about 3-{4-[1-(4-cyclohex-1-enyl-phenyl)-3-(3,5-dichloro-phenyl)-ureidomethyl]-benzoylamino}-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 428815-72-9
3-{4-[(4-cyclohex-1-enyl-phenylamino)-methyl]-benzoylamino}-propionic acid methyl ester

: 34893-92-0
3,4-dichlorophenyl isocyanate

: 1056595-21-1
3-{4-[1-(4-cyclohex-1-enyl-phenyl)-3-(3,5-dichloro-phenyl)-ureidomethyl]-benzoylamino}-propionic acid methyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 21h; Heating;
DOI:10.1021/jm058026u

Reference yield:

: 307990-17-6
4-[1-(4-Cyclohex-1-enylphenyl)-3-(3,5-dichlorophenyl)ureidomethyl]benzoic acid

: 3196-73-4
methyl 3-aminopropanoate hydrochloride

: 1056595-21-1
3-{4-[1-(4-cyclohex-1-enyl-phenyl)-3-(3,5-dichloro-phenyl)-ureidomethyl]-benzoylamino}-propionic acid methyl ester

Guidance literature:: 4-[1-(4-Cyclohex-1-enylphenyl)-3-(3,5-dichlorophenyl)ureidomethyl]benzoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 0.5h;

methyl 3-aminopropanoate hydrochloride; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1021/jm7015599

Reference yield:

: 307989-15-7
3-(4-formylbenzoylamino)propionic acid methyl ester

: 1056595-21-1
3-{4-[1-(4-cyclohex-1-enyl-phenyl)-3-(3,5-dichloro-phenyl)-ureidomethyl]-benzoylamino}-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: triethyl ortoformate; acetic acid; NaCNBH₃ / dimethylformamide / 16 h / 20 °C

2: N,N-DIPEA / acetonitrile / 21 h / 20 °C / Heating

With sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine; orthoformic acid triethyl ester; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm058026u