5,6-Difluorooxindole

Base Information

Chemical Name:5,6-Difluorooxindole
CAS No.:71294-07-0
Molecular Formula:C8H5F2NO
Molecular Weight:169.13
Hs Code.:2933790090
DSSTox Substance ID:DTXSID70503417
Wikidata:Q72463593
Mol file:71294-07-0.mol

Synonyms:5,6-Difluorooxindole;71294-07-0;5,6-difluoroindolin-2-one;5,6-Difluoro-2-oxoindole;5,6-difluoro-1,3-dihydroindol-2-one;5,6-Difluoro-1,3-dihydro-2H-indol-2-one;MFCD01075216;5,6-Difluoro-2-oxindole;2H-Indol-2-one, 5,6-difluoro-1,3-dihydro-;5,6-difluoroxindole;5, 6-difluorooxindole;5,6-difluoro-oxindole;5,6-difluoro-2,3-dihydro-1H-indol-2-one;5 pound not6-Difluorooxindole;SCHEMBL548762;AMY3654;DTXSID70503417;MSOLDJZABLHVER-UHFFFAOYSA-N;AKOS005215809;CS-W022276;MC10114;SB64225;5,6-difluoro-1,3-dihydro-indol-2-one;AC-22691;DS-12867;SY008528;A9348;FT-0601326;W16701;J-516525

Suppliers and Price of 5,6-Difluorooxindole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5,6-Difluorooxindole
50mg
$ 45.00

SynQuest Laboratories
5,6-Difluorooxindole
1 g
$ 136.00

Crysdot
5,6-Difluorooxindole 95+%
1g
$ 125.00

Chemenu
5,6-DIFLUOROOXINDOLE 95%
10g
$ 386.00

Chemenu
5,6-DIFLUOROOXINDOLE 95%
5g
$ 207.00

Apolloscientific
5,6-Difluorooxindole 95+%
1g
$ 85.00

American Custom Chemicals Corporation
5,6-DIFLUOROOXINDOLE 95.00%
1G
$ 757.00

AK Scientific
5,6-Difluoro-2-oxoindole
1g
$ 157.00

AHH
5,6-Difluorooxindole 98%
5g
$ 476.00

Abosyn
5,6-Difluorooxindole 95+%
1g
$ 108.00

Total 52 raw suppliers

Chemical Property of 5,6-Difluorooxindole

Chemical Property:

Vapor Pressure:0.12mmHg at 25°C
Melting Point:201-202 °C(Solv: benzene (71-43-2))
Refractive Index:1.355
Boiling Point:285.259 °C at 760 mmHg
PKA:11.88±0.20(Predicted)
Flash Point:126.32 °C
PSA：29.10000
Density:1.187 g/cm³
LogP:1.59740
Storage Temp.:Sealed in dry,Room Temperature
XLogP3:1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:169.03392011
Heavy Atom Count:12
Complexity:209

Purity/Quality:

99% ^*data from raw suppliers

5,6-Difluorooxindole ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi,Xn
Hazard Codes:Xi,Xn
Statements: 20/21/22-36/37/38
Safety Statements: 26-36/37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C2=CC(=C(C=C2NC1=O)F)F

Technology Process of 5,6-Difluorooxindole

There total 4 articles about 5,6-Difluorooxindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 774-47-0
5,6-difluoro-1H-indole-2,3-dione

: 71294-07-0
5,6-difluoro-1,3-dihydro-indol-2-one

Guidance literature:: With titanium tetrachloride; zinc; In tetrahydrofuran; at 20 ℃; for 0.0833333h; Inert atmosphere;
DOI:10.1016/j.tetlet.2014.02.072

Reference yield: 57.0%

: 76778-13-7
2-chloro-N-(3,4-difluorophenyl)acetamide

: 71294-07-0
5,6-difluoro-1,3-dihydro-indol-2-one

Guidance literature:: With aluminium trichloride; at 200 - 210 ℃; for 4.5h;

Reference yield:

: 3863-11-4
3,4-difluoroaniline

: 71294-07-0
5,6-difluoro-1,3-dihydro-indol-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / pyridine / benzene / Ambient temperature

2: 57 percent / aluminium chloride / 4.5 h / 200 - 210 °C

With pyridine; aluminium trichloride; In benzene;