(2S)-N-(tert-butoxycarbonyl)phenylalanyl-β-alanyl-[α-methyl (2R)-glutamyl]-γ-(2S)-prolyl-[α-methyl (2R)-aspartate] diester

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Chemical Name:(2S)-N-(tert-butoxycarbonyl)phenylalanyl-β-alanyl-[α-methyl (2R)-glutamyl]-γ-(2S)-prolyl-[α-methyl (2R)-aspartate] diester
CAS No.:195301-91-8
Molecular Formula:C₃₃H₄₇N₅O₁₂
Molecular Weight:705.762
Hs Code.:

Synonyms:(2S)-N-(tert-butoxycarbonyl)phenylalanyl-β-alanyl-[α-methyl (2R)-glutamyl]-γ-(2S)-prolyl-[α-methyl (2R)-aspartate] diester

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Chemical Property of (2S)-N-(tert-butoxycarbonyl)phenylalanyl-β-alanyl-[α-methyl (2R)-glutamyl]-γ-(2S)-prolyl-[α-methyl (2R)-aspartate] diester

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Technology Process of (2S)-N-(tert-butoxycarbonyl)phenylalanyl-β-alanyl-[α-methyl (2R)-glutamyl]-γ-(2S)-prolyl-[α-methyl (2R)-aspartate] diester

There total 11 articles about (2S)-N-(tert-butoxycarbonyl)phenylalanyl-β-alanyl-[α-methyl (2R)-glutamyl]-γ-(2S)-prolyl-[α-methyl (2R)-aspartate] diester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 195301-90-7
β-benzyl (2S)-N-(tert-butoxycarbonyl)phenylalanyl-β-alanyl-[α-methyl (2R)-glutamyl]-γ-(2S)-prolyl-[α-methyl (2R)-aspartate] triester

: 195301-91-8
(2S)-N-(tert-butoxycarbonyl)phenylalanyl-β-alanyl-[α-methyl (2R)-glutamyl]-γ-(2S)-prolyl-[α-methyl (2R)-aspartate] diester

Guidance literature:: With hydrogen; 10percent Pd/C; In ethanol; at 20 ℃; for 3h;
DOI:10.1039/b100401h

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 195301-91-8
(2S)-N-(tert-butoxycarbonyl)phenylalanyl-β-alanyl-[α-methyl (2R)-glutamyl]-γ-(2S)-prolyl-[α-methyl (2R)-aspartate] diester

Guidance literature:: Multi-step reaction with 7 steps

1: NMM / tetrahydrofuran; dimethylformamide / 0.08 h / -15 °C

2: 343 mg / NMM / tetrahydrofuran; dimethylformamide / 12 h / -15 - 20 °C

3: 93 percent / HCl / ethyl acetate / 4 h / 0 - 20 °C

4: 566 mg / NMM / tetrahydrofuran; dimethylformamide / 12 h / -15 - 20 °C

5: 95 percent / HCl / ethyl acetate / 2 h / 0 - 20 °C

6: 390 mg / NMM / tetrahydrofuran; dimethylformamide / 12 h / -15 - 20 °C

7: 99 percent / H₂ / 10percent Pd/C / ethanol / 3 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; hydrogen; 10percent Pd/C; In tetrahydrofuran; ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1039/b100401h

Reference yield:

: 84890-94-8
(S)-2-Isobutoxycarbonyloxycarbonyl-pyrrolidine-1-carboxylic acid tert-butyl ester

: 195301-91-8
(2S)-N-(tert-butoxycarbonyl)phenylalanyl-β-alanyl-[α-methyl (2R)-glutamyl]-γ-(2S)-prolyl-[α-methyl (2R)-aspartate] diester

Guidance literature:: Multi-step reaction with 6 steps

1: 343 mg / NMM / tetrahydrofuran; dimethylformamide / 12 h / -15 - 20 °C

2: 93 percent / HCl / ethyl acetate / 4 h / 0 - 20 °C

3: 566 mg / NMM / tetrahydrofuran; dimethylformamide / 12 h / -15 - 20 °C

4: 95 percent / HCl / ethyl acetate / 2 h / 0 - 20 °C

5: 390 mg / NMM / tetrahydrofuran; dimethylformamide / 12 h / -15 - 20 °C

6: 99 percent / H₂ / 10percent Pd/C / ethanol / 3 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; hydrogen; 10percent Pd/C; In tetrahydrofuran; ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1039/b100401h