dimethyl 2-[1-(4-toluenesulfonyl)-1H-indol-3-yl]cyclopropane-1,1-dicarboxylate

Base Information

Chemical Name:dimethyl 2-[1-(4-toluenesulfonyl)-1H-indol-3-yl]cyclopropane-1,1-dicarboxylate
CAS No.:1181824-71-4
Molecular Formula:C₂₂H₂₁NO₆S
Molecular Weight:427.478
Hs Code.:

Synonyms:dimethyl 2-[1-(4-toluenesulfonyl)-1H-indol-3-yl]cyclopropane-1,1-dicarboxylate

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Chemical Property of dimethyl 2-[1-(4-toluenesulfonyl)-1H-indol-3-yl]cyclopropane-1,1-dicarboxylate

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Technology Process of dimethyl 2-[1-(4-toluenesulfonyl)-1H-indol-3-yl]cyclopropane-1,1-dicarboxylate

There total 3 articles about dimethyl 2-[1-(4-toluenesulfonyl)-1H-indol-3-yl]cyclopropane-1,1-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1774-47-6
trimethylsulfoxonium iodide

: methyl 4-(N-p-toluenesulfonyl-3-indolyl)-3-carbomethoxybutenoate

: 1181824-71-4
dimethyl 2-[1-(4-toluenesulfonyl)-1H-indol-3-yl]cyclopropane-1,1-dicarboxylate

Guidance literature:: With sodium hydride; In dimethyl sulfoxide; at 25 ℃; for 24h; Inert atmosphere;
DOI:10.1021/acs.orglett.5b01014

Reference yield: 87.0%

: methyl 4-(N-p-toluenesulfonyl-3-indolyl)-3-carbomethoxybutenoate

: 1181824-71-4
dimethyl 2-[1-(4-toluenesulfonyl)-1H-indol-3-yl]cyclopropane-1,1-dicarboxylate

Guidance literature:: With trimethylsulfoxonium iodide; sodium hydride; In dimethyl sulfoxide; at 20 ℃; for 4h; Inert atmosphere;
DOI:10.1002/chem.201101687

Reference yield:

: 50562-79-3
1-(4-tolylsulfonyl)indole-3-carboxaldehyde

: 1181824-71-4
dimethyl 2-[1-(4-toluenesulfonyl)-1H-indol-3-yl]cyclopropane-1,1-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; titanium tetrachloride / tetrahydrofuran; dichloromethane / 3 h / 0 - 20 °C

2: trimethylsulfoxonium iodide; sodium hydride / dimethyl sulfoxide / 4 h / 20 °C / Inert atmosphere

With pyridine; trimethylsulfoxonium iodide; titanium tetrachloride; sodium hydride; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1002/chem.201101687