Toluol-sulfonsaeure-(4)-<11β-hydroxy-21-acetoxy-20-oxo-5α-pregnanyl-(3β)-ester>

Base Information

• Chemical Name: Toluol-sulfonsaeure-(4)-<11β-hydroxy-21-acetoxy-20-oxo-5α-pregnanyl-(3β)-ester>
• CAS No.: 4131-16-2
• Molecular Formula: C₃₀H₄₂O₇S
• Molecular Weight: 546.725
• Mol file: 4131-16-2.mol

Synonyms:Toluol-sulfonsaeure-(4)-<11β-hydroxy-21-acetoxy-20-oxo-5α-pregnanyl-(3β)-ester>

Chemical Property of Toluol-sulfonsaeure-(4)-<11β-hydroxy-21-acetoxy-20-oxo-5α-pregnanyl-(3β)-ester>

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Toluol-sulfonsaeure-(4)-<11β-hydroxy-21-acetoxy-20-oxo-5α-pregnanyl-(3β)-ester>

There total 4 articles about Toluol-sulfonsaeure-(4)-<11β-hydroxy-21-acetoxy-20-oxo-5α-pregnanyl-(3β)-ester> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

corticosterone-21-acetate (1173-26-8) → Toluol-sulfonsaeure-(4)-<11β-hydroxy-21-acetoxy-20-oxo-5α-pregnanyl-(3β)-ester> (4131-16-2)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / Pd-C / ethyl acetate

2: H₂ / Raney-Ni / dioxane

3: Py

With pyridine; hydrogen; palladium on activated charcoal; nickel; In 1,4-dioxane; ethyl acetate;

DOI:10.1016/0039-128X(63)90025-4

Reference yield:

2-((5S,8S,9S,10S,11S,13S,14S,17S)-11-hydroxy-10,13-dimethyl-3-oxo-hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate (884311-46-0) → Toluol-sulfonsaeure-(4)-<11β-hydroxy-21-acetoxy-20-oxo-5α-pregnanyl-(3β)-ester> (4131-16-2)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Raney-Ni / dioxane

2: Py

With pyridine; hydrogen; nickel; In 1,4-dioxane;

DOI:10.1016/0039-128X(63)90025-4

Reference yield:

21-acetoxy-3β,11β-dihydroxy-5α-pregnan-20-one (57717-95-0) + p-toluenesulfonyl chloride (98-59-9) → Toluol-sulfonsaeure-(4)-<11β-hydroxy-21-acetoxy-20-oxo-5α-pregnanyl-(3β)-ester> (4131-16-2)

Guidance literature:

With pyridine;

DOI:10.1016/0039-128X(63)90025-4

upstream raw materials:

21-acetoxy-3β,11β-dihydroxy-5α-pregnan-20-one

p-toluenesulfonyl chloride

2-((5S,8S,9S,10S,11S,13S,14S,17S)-11-hydroxy-10,13-dimethyl-3-oxo-hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate

corticosterone-21-acetate

Downstream raw materials:

5α-pregnan-3α,11β,21-triol-20-one