3-amino-4-[5-(trans-4-tert-butyl-cyclohexyloxy)-2,3-dihydro-indol-1-yl]-4-oxo-butyric acid trifluoroacetate

Base Information

Chemical Name:3-amino-4-[5-(trans-4-tert-butyl-cyclohexyloxy)-2,3-dihydro-indol-1-yl]-4-oxo-butyric acid trifluoroacetate
CAS No.:1266116-41-9
Molecular Formula:C₂HF₃O₂*C₂₂H₃₂N₂O₄
Molecular Weight:502.531
Hs Code.:

Synonyms:3-amino-4-[5-(trans-4-tert-butyl-cyclohexyloxy)-2,3-dihydro-indol-1-yl]-4-oxo-butyric acid trifluoroacetate

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Chemical Property of 3-amino-4-[5-(trans-4-tert-butyl-cyclohexyloxy)-2,3-dihydro-indol-1-yl]-4-oxo-butyric acid trifluoroacetate

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Technology Process of 3-amino-4-[5-(trans-4-tert-butyl-cyclohexyloxy)-2,3-dihydro-indol-1-yl]-4-oxo-butyric acid trifluoroacetate

There total 7 articles about 3-amino-4-[5-(trans-4-tert-butyl-cyclohexyloxy)-2,3-dihydro-indol-1-yl]-4-oxo-butyric acid trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1266116-37-3
3-tert-butoxycarbonylamino-4-[5-(trans-4-tert-butyl-cyclohexyloxy)-2,3-dihydro-indol-1-yl]-4-oxo-butyric acid tert-butyl ester

: 76-05-1
trifluoroacetic acid

: 1266116-41-9
3-amino-4-[5-(trans-4-tert-butyl-cyclohexyloxy)-2,3-dihydro-indol-1-yl]-4-oxo-butyric acid trifluoroacetate

Guidance literature:: In dichloromethane; at 20 ℃;

Reference yield:

: 172078-33-0
2,3-Dihydro-1H-indol-5-ol

: 1266116-41-9
3-amino-4-[5-(trans-4-tert-butyl-cyclohexyloxy)-2,3-dihydro-indol-1-yl]-4-oxo-butyric acid trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydrogencarbonate / chloroform / 20 °C

2: caesium carbonate / butanone; tert-butyl alcohol / 100 °C / Sealed tube

3: hydrogenchloride / 1,4-dioxane; tetrahydrofuran / 48 h / 20 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide

5: dichloromethane / 20 °C

With hydrogenchloride; sodium hydrogencarbonate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform; N,N-dimethyl-formamide; butanone; tert-butyl alcohol;

Reference yield:

: 170147-76-9
tert-butyl 5-hydroxy-2,3-dihydroindole-1-carboxylate

: 1266116-41-9
3-amino-4-[5-(trans-4-tert-butyl-cyclohexyloxy)-2,3-dihydro-indol-1-yl]-4-oxo-butyric acid trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / butanone; tert-butyl alcohol / 100 °C / Sealed tube

2: hydrogenchloride / 1,4-dioxane; tetrahydrofuran / 48 h / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide

4: dichloromethane / 20 °C

With hydrogenchloride; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; butanone; tert-butyl alcohol;