(S₂,R_S)-3,3-dimethyl-2-hydroxy-2-<<(4-methylphenyl)sulfinyl>methyl>butanenitrile

Base Information

• Chemical Name: (S₂,R_S)-3,3-dimethyl-2-hydroxy-2-<<(4-methylphenyl)sulfinyl>methyl>butanenitrile
• CAS No.: 136347-11-0
• Molecular Formula: C₁₄H₁₉NO₂S
• Molecular Weight: 265.376
• Mol file: 136347-11-0.mol

Synonyms:(S₂,R_S)-3,3-dimethyl-2-hydroxy-2-<<(4-methylphenyl)sulfinyl>methyl>butanenitrile

Chemical Property of (S₂,R_S)-3,3-dimethyl-2-hydroxy-2-<<(4-methylphenyl)sulfinyl>methyl>butanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S₂,R_S)-3,3-dimethyl-2-hydroxy-2-<<(4-methylphenyl)sulfinyl>methyl>butanenitrile

There total 1 articles about (S₂,R_S)-3,3-dimethyl-2-hydroxy-2-<<(4-methylphenyl)sulfinyl>methyl>butanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

diethylaluminium cyanide (5804-85-3) + (R)-(+)-3,3-dimethyl-1-(4-methylphenylsulfinyl)-2-butanone (71899-71-3) → (S2,RS)-3,3-dimethyl-2-hydroxy-2-<<(4-methylphenyl)sulfinyl>methyl>butanenitrile (136347-11-0)

Guidance literature:

With zinc(II) chloride; In tetrahydrofuran; toluene; for 2h; Product distribution; Mechanism; Ambient temperature; other Lewis acids, without Lewis acid; other substrates; diastereoselectivity;

DOI:10.1021/jo00052a044

Reference yield: 89.0%

(S2,RS)-3,3-dimethyl-2-hydroxy-2-<<(4-methylphenyl)sulfinyl>methyl>butanenitrile (136347-11-0) → (S2,RS)-3,3-dimethyl-2-hydroxy-2-<<(4-methylphenyl)sufinyl>methyl>butanamide (144694-94-0)

Guidance literature:

With hydrogenchloride; In methanol; for 24h; Heating;

DOI:10.1021/jo00082a008

Reference yield: 35.0%

(S2,RS)-3,3-dimethyl-2-hydroxy-2-<<(4-methylphenyl)sulfinyl>methyl>butanenitrile (136347-11-0) → (S)-3,3-dimethyl-2-hydroxy-2-<<(4-methylphenyl)sulfenyl>methyl>butanamide (136347-15-4) + (S2,RS)-3,3-dimethyl-2-hydroxy-2-<<(4-methylphenyl)sufinyl>methyl>butanamide (144694-94-0)

Guidance literature:

With hydrogenchloride; In diethyl ether; at 0 ℃; for 1h;

DOI:10.1021/jo00052a044

upstream raw materials:

diethylaluminium cyanide

(R)-(+)-3,3-dimethyl-1-(4-methylphenylsulfinyl)-2-butanone

Downstream raw materials:

(S)-3,3-dimethyl-2-hydroxy-2-<<(4-methylphenyl)sulfenyl>methyl>butanamide

(S₂,R_S)-3,3-dimethyl-2-hydroxy-2-<<(4-methylphenyl)sufinyl>methyl>butanamide

(R)-2-tert-Butyloxirane-2-carboxamide