5-[2-(4-methoxy-benzyloxy)-ethyl]-2,3-dihydro-[1,4]dithiine

Base Information

• Chemical Name: 5-[2-(4-methoxy-benzyloxy)-ethyl]-2,3-dihydro-[1,4]dithiine
• CAS No.: 605671-63-4
• Molecular Formula: C₁₄H₁₈O₂S₂
• Molecular Weight: 282.428
• Mol file: 605671-63-4.mol

Synonyms:5-[2-(4-methoxy-benzyloxy)-ethyl]-2,3-dihydro-[1,4]dithiine

Chemical Property of 5-[2-(4-methoxy-benzyloxy)-ethyl]-2,3-dihydro-[1,4]dithiine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-[2-(4-methoxy-benzyloxy)-ethyl]-2,3-dihydro-[1,4]dithiine

There total 3 articles about 5-[2-(4-methoxy-benzyloxy)-ethyl]-2,3-dihydro-[1,4]dithiine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

p-methoxybenzyl chloride (824-94-2) + 5,6-dihydro-1,4-dithiin (605671-62-3) → 5-[2-(4-methoxy-benzyloxy)-ethyl]-2,3-dihydro-[1,4]dithiine (605671-63-4)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 15h;

DOI:10.1002/ejoc.200300025

Reference yield:

2-[3'-(benzoyloxy)propyl]-1,3-dithiolane (605671-58-7) → 5-[2-(4-methoxy-benzyloxy)-ethyl]-2,3-dihydro-[1,4]dithiine (605671-63-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / NBS / CHCl₃ / 16 h / 20 °C

2: 98 percent / MeONa / methanol / 4 h / 20 °C

3: 96 percent / NaH / dimethylformamide / 15 h / 20 °C

With N-Bromosuccinimide; sodium methylate; sodium hydride; In methanol; chloroform; N,N-dimethyl-formamide;

DOI:10.1002/ejoc.200300025

Reference yield:

5,6-dihydro-1,4-dithiin (605671-59-8) → 5-[2-(4-methoxy-benzyloxy)-ethyl]-2,3-dihydro-[1,4]dithiine (605671-63-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / MeONa / methanol / 4 h / 20 °C

2: 96 percent / NaH / dimethylformamide / 15 h / 20 °C

With sodium methylate; sodium hydride; In methanol; N,N-dimethyl-formamide;

DOI:10.1002/ejoc.200300025

upstream raw materials:

p-methoxybenzyl chloride

5,6-dihydro-1,4-dithiin

2-[3'-(benzoyloxy)propyl]-1,3-dithiolane

5,6-dihydro-1,4-dithiin