ethyl (3R)-3-(N-Boc-Gly)amino-3-(5-chloro-2-hydroxy-3-iodophenyl)propionate

Base Information

Chemical Name:ethyl (3R)-3-(N-Boc-Gly)amino-3-(5-chloro-2-hydroxy-3-iodophenyl)propionate
CAS No.:726191-25-9
Molecular Formula:C₁₈H₂₄ClIN₂O₆
Molecular Weight:526.756
Hs Code.:

Synonyms:ethyl (3R)-3-(N-Boc-Gly)amino-3-(5-chloro-2-hydroxy-3-iodophenyl)propionate

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Chemical Property of ethyl (3R)-3-(N-Boc-Gly)amino-3-(5-chloro-2-hydroxy-3-iodophenyl)propionate

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Technology Process of ethyl (3R)-3-(N-Boc-Gly)amino-3-(5-chloro-2-hydroxy-3-iodophenyl)propionate

There total 1 articles about ethyl (3R)-3-(N-Boc-Gly)amino-3-(5-chloro-2-hydroxy-3-iodophenyl)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: ethyl (3R)-3-amino-3-(5-chloro-2-hydroxy-3-iodophenyl)propionate p-toluenesulfonic acid salt

: 3392-07-2
tert-butyl N-{2-[(2,5-dioxopyrrolidin-1-yl)oxy]-2-oxoethyl}carbamate

: 726191-25-9
ethyl (3R)-3-(N-Boc-Gly)amino-3-(5-chloro-2-hydroxy-3-iodophenyl)propionate

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1016/j.bmc.2007.03.034

Reference yield: 97.0%

: 726191-25-9
ethyl (3R)-3-(N-Boc-Gly)amino-3-(5-chloro-2-hydroxy-3-iodophenyl)propionate

: ethyl (3R)-3-(N-Gly)amino-3-(5-chloro-2-hydroxy-3-iodophenyl)propionate hydrochloride

Guidance literature:: With hydrogenchloride; In ethanol; at 20 ℃; for 3h;
DOI:10.1016/j.bmc.2007.03.034

Reference yield:

: 726191-25-9
ethyl (3R)-3-(N-Boc-Gly)amino-3-(5-chloro-2-hydroxy-3-iodophenyl)propionate

: C₂₂H₂₃ClIN₅O₆C₂H₄

Guidance literature:: Multi-step reaction with 2 steps

1.1: 97 percent / HCl / ethanol / 3 h / 20 °C

2.1: isobutyl chloroformate; N-methylmorpholine / dimethylformamide / 0.25 h / 0 °C

2.2: N-methylmorpholine / dimethylformamide / 0 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; isobutyl chloroformate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2007.03.034