6-<<1,4-bis<(4-methoxybenzyl)oxy>but-2-oxy>amino>-4-chloro-2,5-diformamidopyrimidine

Base Information

• Chemical Name: 6-<<1,4-bis<(4-methoxybenzyl)oxy>but-2-oxy>amino>-4-chloro-2,5-diformamidopyrimidine
• CAS No.: 114809-59-5
• Molecular Formula: C₂₆H₃₀ClN₅O₇
• Molecular Weight: 560.007
• Mol file: 114809-59-5.mol

Synonyms:6-<<1,4-bis<(4-methoxybenzyl)oxy>but-2-oxy>amino>-4-chloro-2,5-diformamidopyrimidine

Chemical Property of 6-<<1,4-bis<(4-methoxybenzyl)oxy>but-2-oxy>amino>-4-chloro-2,5-diformamidopyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-<<1,4-bis<(4-methoxybenzyl)oxy>but-2-oxy>amino>-4-chloro-2,5-diformamidopyrimidine

There total 4 articles about 6-<<1,4-bis<(4-methoxybenzyl)oxy>but-2-oxy>amino>-4-chloro-2,5-diformamidopyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

4,6-dichloro-2,5-diformamido-pyrimidine (116477-30-6) + 1,4-bis<(4-methoxybenzyl)oxy>but-2-oxyamine (114809-58-4) → 6-<<1,4-bis<(4-methoxybenzyl)oxy>but-2-oxy>amino>-4-chloro-2,5-diformamidopyrimidine (114809-59-5)

Guidance literature:

With triethylamine; In 1,4-dioxane; at 100 ℃; for 1.5h;

DOI:10.1021/jm00105a010

Reference yield:

1,4-bis<(4-methoxybenzyl)oxy>but-2-ene (114809-55-1) → 6-<<1,4-bis<(4-methoxybenzyl)oxy>but-2-oxy>amino>-4-chloro-2,5-diformamidopyrimidine (114809-59-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) (CF₃CO₂)2Hg, H₂O, 2.) aq. NaOH, NaBH₄ / 1.) THF, RT, 15 min

2: 63 percent / Ph₃P, diethyl azodicarboxylate (DEAD) / tetrahydrofuran / 24 h / 20 °C

3: 68 percent / methylhydrazine / CH₂Cl₂ / 0.67 h / Ambient temperature

4: 62 percent / Et₃N / dioxane / 1.5 h / 100 °C

With sodium hydroxide; sodium tetrahydroborate; water; mercury(II) trifluoroacetate; triethylamine; triphenylphosphine; methylhydrazine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; dichloromethane;

DOI:10.1021/jm00105a010

Reference yield:

N-<1,4-bis<(4-methoxybenzyl)oxy>but-2-oxy>phthalimide (131068-38-7) → 6-<<1,4-bis<(4-methoxybenzyl)oxy>but-2-oxy>amino>-4-chloro-2,5-diformamidopyrimidine (114809-59-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / methylhydrazine / CH₂Cl₂ / 0.67 h / Ambient temperature

2: 62 percent / Et₃N / dioxane / 1.5 h / 100 °C

With triethylamine; methylhydrazine; In 1,4-dioxane; dichloromethane;

DOI:10.1021/jm00105a010

upstream raw materials:

4,6-dichloro-2,5-diformamido-pyrimidine

1,4-bis<(4-methoxybenzyl)oxy>but-2-oxyamine

1,4-bis<(4-methoxybenzyl)oxy>but-2-ene

N-<1,4-bis<(4-methoxybenzyl)oxy>but-2-oxy>phthalimide

Downstream raw materials:

2-amino-9-<1,4-bis<(4-methoxybenzyl)oxy>but-2-oxy>-6-chloropurine

9-<1,4-bis<(4-methoxybenzyl)oxy>but-2-oxy>-6-chloro-2-formamidopurine