ethyl 1-(2,4-dichlorobenzyl)-5-(1H-indol-3-yl)-1H-pyrazole-3-carboxylate

Base Information

• Chemical Name: ethyl 1-(2,4-dichlorobenzyl)-5-(1H-indol-3-yl)-1H-pyrazole-3-carboxylate
• CAS No.: 1350730-40-3
• Molecular Formula: C₂₁H₁₇Cl₂N₃O₂
• Molecular Weight: 414.291
• Mol file: 1350730-40-3.mol

Synonyms:ethyl 1-(2,4-dichlorobenzyl)-5-(1H-indol-3-yl)-1H-pyrazole-3-carboxylate

Chemical Property of ethyl 1-(2,4-dichlorobenzyl)-5-(1H-indol-3-yl)-1H-pyrazole-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 1-(2,4-dichlorobenzyl)-5-(1H-indol-3-yl)-1H-pyrazole-3-carboxylate

There total 1 articles about ethyl 1-(2,4-dichlorobenzyl)-5-(1H-indol-3-yl)-1H-pyrazole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

C14H13N3O2 (51843-30-2) + 2,4-Dichlorobenzyl chloride (94-99-5) → ethyl 1-(2,4-dichlorobenzyl)-5-(1H-indol-3-yl)-1H-pyrazole-3-carboxylate (1350730-40-3) + ethyl 1-(2,4-dichlorobenzyl)-3-(1H-indol-3-yl)-1H-pyrazole-5-carboxylate (1350730-37-8)

Guidance literature:

With potassium bromide; potassium hydroxide; In dimethyl sulfoxide; at 0 ℃; for 1.5h; Inert atmosphere;

DOI:10.1016/j.ejmech.2011.09.049

Reference yield: 85.0%

ethyl 1-(2,4-dichlorobenzyl)-5-(1H-indol-3-yl)-1H-pyrazole-3-carboxylate (1350730-40-3) + propyl bromide (106-94-5) → ethyl 1-(2,4-dichlorobenzyl)-5-(1-propyl-1H-indol-3-yl)-1H-pyrazole-3-carboxylate (1350730-63-0)

Guidance literature:

ethyl 1-(2,4-dichlorobenzyl)-5-(1H-indol-3-yl)-1H-pyrazole-3-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; at 10 ℃; for 0.166667h;

propyl bromide; In N,N-dimethyl-formamide; at 10 - 20 ℃; for 1h;

DOI:10.1016/j.ejmech.2011.09.049

upstream raw materials:

C₁₄H₁₃N₃O₂

2,4-Dichlorobenzyl chloride

Downstream raw materials:

ethyl 1-(2,4-dichlorobenzyl)-5-(1-propyl-1H-indol-3-yl)-1H-pyrazole-3-carboxylate