6-(3-Aminophenyl)-4-methyl-N-2H-tetrazol-5-yl-2-pyridinecarboxamide

Base Information

Chemical Name:6-(3-Aminophenyl)-4-methyl-N-2H-tetrazol-5-yl-2-pyridinecarboxamide
CAS No.:86696-40-4
Molecular Formula:C₁₄H₁₃N₇O
Molecular Weight:295.304
Hs Code.:
ChEMBL ID:CHEMBL290697
DSSTox Substance ID:DTXSID901163496

Synonyms:CHEMBL290697;DTXSID901163496;6-(3-Aminophenyl)-4-methyl-N-2H-tetrazol-5-yl-2-pyridinecarboxamide;86696-40-4

Suppliers and Price of 6-(3-Aminophenyl)-4-methyl-N-2H-tetrazol-5-yl-2-pyridinecarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-(3-Aminophenyl)-4-methyl-N-2H-tetrazol-5-yl-2-pyridinecarboxamide

Chemical Property:

XLogP3:1.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:295.11815806
Heavy Atom Count:22
Complexity:393

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC(=NC(=C1)C(=O)NC2=NNN=N2)C3=CC(=CC=C3)N

Technology Process of 6-(3-Aminophenyl)-4-methyl-N-2H-tetrazol-5-yl-2-pyridinecarboxamide

There total 6 articles about 6-(3-Aminophenyl)-4-methyl-N-2H-tetrazol-5-yl-2-pyridinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 80021-43-8
N-(5-tetrazolyl)-4-methyl-6-(3-nitrophenyl)-2-pyridinecarboxamide

: 86696-40-4
6-(3-Amino-phenyl)-4-methyl-pyridine-2-carboxylic acid (1H-tetrazol-5-yl)-amide

Guidance literature:: With sodium hydroxide; hydrogen; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00364a026

Reference yield:

: 20807-64-1
4-methyl-2-(4-nitrophenyl)pyridine

: 86696-40-4
6-(3-Amino-phenyl)-4-methyl-pyridine-2-carboxylic acid (1H-tetrazol-5-yl)-amide

Guidance literature:: Multi-step reaction with 6 steps

1: 30percent aq. H₂O₂ / acetic acid / 20 h / 80 °C

2: 1.) Me₂SO₄ / 1.) 80-90 deg C, 2 h, 2.) dioxane, H₂O, RT, 30 min

3: 5 M aq. HCl / 11 h / Heating

4: SOCl₂ / 1 h / Heating

5: Et₃N / dimethylformamide / 2 h / 80 °C

6: 93 percent / aq. NaOH, H₂ / 10percent Pd/C / ethanol

With hydrogenchloride; sodium hydroxide; thionyl chloride; hydrogen; dihydrogen peroxide; triethylamine; dimethyl sulfate; palladium on activated charcoal; In ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00364a026

Reference yield:

: 80021-68-7
2-cyano-4-methyl-6-(4-nitrophenyl)pyridine

: 86696-40-4
6-(3-Amino-phenyl)-4-methyl-pyridine-2-carboxylic acid (1H-tetrazol-5-yl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1: 5 M aq. HCl / 11 h / Heating

2: SOCl₂ / 1 h / Heating

3: Et₃N / dimethylformamide / 2 h / 80 °C

4: 93 percent / aq. NaOH, H₂ / 10percent Pd/C / ethanol

With hydrogenchloride; sodium hydroxide; thionyl chloride; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00364a026