2-Hydroxy-6-methylpyridine-3,4-dicarboxylic acid

Base Information

• Chemical Name: 2-Hydroxy-6-methylpyridine-3,4-dicarboxylic acid
• CAS No.: 2860-55-1
• Molecular Formula: C₈H₇NO₅
• Molecular Weight: 197.147
• Hs Code.: 2933399090
• NSC Number: 126866
• DSSTox Substance ID: DTXSID40298904
• Wikidata: Q82041011
• ChEMBL ID: CHEMBL1684099
• Mol file: 2860-55-1.mol

Synonyms:2-Hydroxy-6-methylpyridine-3,4-dicarboxylic acid;2860-55-1;6-methyl-2-oxo-1H-pyridine-3,4-dicarboxylic acid;6-methyl-2-oxo-1,2-dihydropyridine-3,4-dicarboxylic acid;NSC-126866;NSC126866;2-Hydroxy-6-methylpyridine-3,4-dicarboxylicacid;CHEMBL1684099;DTXSID40298904;CAA86055;MFCD20639298;FS-6199;SB52791;CS-0081571;D74334;A876678

Chemical Property of 2-Hydroxy-6-methylpyridine-3,4-dicarboxylic acid

Chemical Property:

• Vapor Pressure: 5.12E-08mmHg at 25°C
• Boiling Point: 414.1°Cat760mmHg
• Flash Point: 204.2°C
• PSA: 107.46000
• Density: 1.589g/cm³
• LogP: 0.07970
• Storage Temp.: 2-8°C
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 197.03242232
• Heavy Atom Count: 14
• Complexity: 391

Purity/Quality:

97% ^*data from raw suppliers

2-Hydroxy-6-methylpyridine-3,4-dicarboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C(=O)N1)C(=O)O)C(=O)O

Technology Process of 2-Hydroxy-6-methylpyridine-3,4-dicarboxylic acid

There total 3 articles about 2-Hydroxy-6-methylpyridine-3,4-dicarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-cyano-2-hydroxy-6-methyl-isonicotinic acid amide (90110-69-3) → 2-hydroxy-6-methylpyridine-3,4-dicarboxylic acid (2860-55-1)

Guidance literature:

With hydrogenchloride; sodium nitrite;

Reference yield:

→ 1,2-Dihydro-6-methyl-2-oxocinchomeronsaeure (2860-55-1)

Guidance literature:

Albofungol Ia, KMnO4;

Reference yield:

→ 2-hydroxy-6-methylpyridine-3,4-dicarboxylic acid (2860-55-1)

Guidance literature:

4-Ethoxycarbonyl-3-cyan-2-hydroxy-6-methyl-pyridin, wss. NaOH, Δ;

upstream raw materials:

3-cyano-2-hydroxy-6-methyl-isonicotinic acid amide

Downstream raw materials:

dimethyl 2-chloro-6-methylpyridine-3,4-dicarboxylate

2-Chloro-6-methyl-pyridine-3,4-dicarboxylic acid 4-methyl ester

7-methyl-4-oxo-1-phenyl-2-thioxo-1,2,3,4-tetrahydro-pyrido[2,3-d]pyrimidine-5-carboxylic acid

1-Butyl-7-methyl-4-oxo-3-phenyl-2-thioxo-1,2,3,4-tetrahydro-pyrido[2,3-d]pyrimidine-5-carboxylic acid methyl ester