4-cyclohexyl-1-(4-chlorophenyl)[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one

Base Information

• Chemical Name: 4-cyclohexyl-1-(4-chlorophenyl)[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one
• CAS No.: 1041188-05-9
• Molecular Formula: C₂₁H₁₉ClN₄O
• Molecular Weight: 378.861

Synonyms:4-cyclohexyl-1-(4-chlorophenyl)[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one

Chemical Property of 4-cyclohexyl-1-(4-chlorophenyl)[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one

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Technology Process of 4-cyclohexyl-1-(4-chlorophenyl)[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one

There total 1 articles about 4-cyclohexyl-1-(4-chlorophenyl)[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4-chlorobenzaldehyde N-(3-cyclohexyl-3,4-dihydro-4-oxoquinazolin-2-yl)hydrazone (1041187-96-5) → 4-cyclohexyl-1-(4-chlorophenyl)[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one (1041188-05-9)

Guidance literature:

With iron(III) chloride; In ethanol; for 0.5h; Reflux;

DOI:10.3987/COM-07-11311

Reference yield: 82.0%

4-cyclohexyl-1-(4-chlorophenyl)[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one (1041188-05-9) → 2-(4-chlorophenyl)-4-cyclohexyl[1,2,4]triazolo[1,5-a]quinazolin-5(4H)-one (1041188-16-2)

Guidance literature:

With potassium hydroxide; In ethanol; for 4h; Reflux;

DOI:10.3987/COM-07-11311

upstream raw materials:

4-chlorobenzaldehyde N-(3-cyclohexyl-3,4-dihydro-4-oxoquinazolin-2-yl)hydrazone

Downstream raw materials:

2-(4-chlorophenyl)-4-cyclohexyl[1,2,4]triazolo[1,5-a]quinazolin-5(4H)-one

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