2-(2-Azido-ethoxymethyl)-6-methyl-4-phenyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester

Base Information

• Chemical Name: 2-(2-Azido-ethoxymethyl)-6-methyl-4-phenyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester
• CAS No.: 103069-43-8
• Molecular Formula: C₂₀H₂₄N₄O₅
• Molecular Weight: 400.434

Synonyms:2-(2-Azido-ethoxymethyl)-6-methyl-4-phenyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester

Chemical Property of 2-(2-Azido-ethoxymethyl)-6-methyl-4-phenyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester

Chemical Property:

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Technology Process of 2-(2-Azido-ethoxymethyl)-6-methyl-4-phenyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester

There total 3 articles about 2-(2-Azido-ethoxymethyl)-6-methyl-4-phenyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl (2-chloroaceto)acetate (638-07-3) → 2-(2-Azido-ethoxymethyl)-6-methyl-4-phenyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester (103069-43-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaH / 1.) THF, RT, 1 h, 2.) THF, RT, 16 h

2: NH₄OAc / ethanol / 1 h / Heating

3: 5 h / Heating

With ammonium acetate; sodium hydride; In ethanol;

DOI:10.1021/jm00159a022

Reference yield:

ethyl 4-(2-azidoethoxy)acetoacetate (88150-45-2) → 2-(2-Azido-ethoxymethyl)-6-methyl-4-phenyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester (103069-43-8)

Guidance literature:

Multi-step reaction with 2 steps

1: NH₄OAc / ethanol / 1 h / Heating

2: 5 h / Heating

With ammonium acetate; In ethanol;

DOI:10.1021/jm00159a022

Reference yield:

(E)-2-acetyl-1-phenyl-prop-1,2-enoic acid methyl ester (20048-06-0,15768-07-7,20048-05-9) + (E)-3-Amino-4-(2-azido-ethoxy)-but-2-enoic acid ethyl ester → 2-(2-Azido-ethoxymethyl)-6-methyl-4-phenyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester (103069-43-8)

Guidance literature:

for 5h; Yield given; Heating;

DOI:10.1021/jm00159a022

upstream raw materials:

(E)-2-acetyl-1-phenyl-prop-1,2-enoic acid methyl ester

ethyl (2-chloroaceto)acetate

ethyl 4-(2-azidoethoxy)acetoacetate

Downstream raw materials:

2-(2-Amino-ethoxymethyl)-6-methyl-4-phenyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester

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