(S)-methyl 4-(2-phenyl-2-(4-(trifluoromethyl)phenylsulfonamido)acetamido)benzoate

Base Information

Chemical Name:(S)-methyl 4-(2-phenyl-2-(4-(trifluoromethyl)phenylsulfonamido)acetamido)benzoate
CAS No.:1587675-67-9
Molecular Formula:C₂₃H₁₉F₃N₂O₅S
Molecular Weight:492.475
Hs Code.:

Synonyms:(S)-methyl 4-(2-phenyl-2-(4-(trifluoromethyl)phenylsulfonamido)acetamido)benzoate

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Chemical Property of (S)-methyl 4-(2-phenyl-2-(4-(trifluoromethyl)phenylsulfonamido)acetamido)benzoate

Chemical Property:

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Technology Process of (S)-methyl 4-(2-phenyl-2-(4-(trifluoromethyl)phenylsulfonamido)acetamido)benzoate

There total 6 articles about (S)-methyl 4-(2-phenyl-2-(4-(trifluoromethyl)phenylsulfonamido)acetamido)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 2991-42-6
4-trifluorophenylsulfonyl chloride

: 1446015-00-4
(S)-methyl 4-(2-amino-2-phenylacetamido)benzoate hydrochloride

: 1587675-67-9
(S)-methyl 4-(2-phenyl-2-(4-(trifluoromethyl)phenylsulfonamido)acetamido)benzoate

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; water; at 20 ℃; for 8h;
DOI:10.1002/cmdc.201300297

Reference yield:

: 2900-27-8
(2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid

: 1587675-67-9
(S)-methyl 4-(2-phenyl-2-(4-(trifluoromethyl)phenylsulfonamido)acetamido)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / tetrahydrofuran / 8 h / 25 °C

2: ethyl acetate; hydrogenchloride / 5 h / 25 °C

3: sodium hydrogencarbonate / water; tetrahydrofuran / 8 h / 20 °C

With hydrogenchloride; sodium hydrogencarbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; ethyl acetate; triethylamine; In tetrahydrofuran; water;
DOI:10.1002/cmdc.201300297

Reference yield:

: 2935-35-5
(S)-2-phenylglycine

: 1587675-67-9
(S)-methyl 4-(2-phenyl-2-(4-(trifluoromethyl)phenylsulfonamido)acetamido)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / methanol; water / 8 h / 25 °C

2: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / tetrahydrofuran / 8 h / 25 °C

3: ethyl acetate; hydrogenchloride / 5 h / 25 °C

4: sodium hydrogencarbonate / water; tetrahydrofuran / 8 h / 20 °C

With hydrogenchloride; sodium hydrogencarbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; ethyl acetate; triethylamine; In tetrahydrofuran; methanol; water;
DOI:10.1002/cmdc.201300297