(S)-4-tert-Butoxycarbonylamino-6-(trityl-carbamoyl)-hexanoic acid ethyl ester

Base Information

Chemical Name:(S)-4-tert-Butoxycarbonylamino-6-(trityl-carbamoyl)-hexanoic acid ethyl ester
CAS No.:1026736-84-4
Molecular Formula:C₃₃H₄₀N₂O₅
Molecular Weight:544.691
Hs Code.:

Synonyms:(S)-4-tert-Butoxycarbonylamino-6-(trityl-carbamoyl)-hexanoic acid ethyl ester

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Chemical Property of (S)-4-tert-Butoxycarbonylamino-6-(trityl-carbamoyl)-hexanoic acid ethyl ester

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Technology Process of (S)-4-tert-Butoxycarbonylamino-6-(trityl-carbamoyl)-hexanoic acid ethyl ester

There total 5 articles about (S)-4-tert-Butoxycarbonylamino-6-(trityl-carbamoyl)-hexanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 199005-58-8
(S,E)-ethyl 4-(tert-butoxycarbonylamino)-7-oxo-7-(tritylamino)-hept-2-enoate

: 1026736-84-4
(S)-4-tert-Butoxycarbonylamino-6-(trityl-carbamoyl)-hexanoic acid ethyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 23 ℃; for 16h;
DOI:10.1021/jm980068d

Reference yield:

: 132388-69-3,210750-95-1
Boc-L-Gln(Trt)-OH

: 1026736-84-4
(S)-4-tert-Butoxycarbonylamino-6-(trityl-carbamoyl)-hexanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 4-methylmorpholine / CH₂Cl₂ / 0.33 h / 0 °C

2: CH₂Cl₂ / 1.) 0 deg C, 20 min, 2.) RT, 2 h

3: diisobutylaluminum hydride / toluene / 4 h / -78 °C

4: 1.) NaN(TMS)2 / 1.) THF, -78 deg C, 20 min, 2.) THF, a) -78 deg C, 2 h, b) from -78 deg C to 0 deg C, 10 min

5: H₂ / 10percent Pd/C / ethanol / 16 h / 23 °C

With 4-methyl-morpholine; hydrogen; sodium hexamethyldisilazane; diisobutylaluminium hydride; palladium on activated charcoal; In ethanol; dichloromethane; toluene;
DOI:10.1021/jm980068d

Reference yield:

: 199005-56-6
[(S)-1-(Methoxy-methyl-carbamoyl)-3-(trityl-carbamoyl)-propyl]-carbamic acid tert-butyl ester

: 1026736-84-4
(S)-4-tert-Butoxycarbonylamino-6-(trityl-carbamoyl)-hexanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: diisobutylaluminum hydride / toluene / 4 h / -78 °C

2: 1.) NaN(TMS)2 / 1.) THF, -78 deg C, 20 min, 2.) THF, a) -78 deg C, 2 h, b) from -78 deg C to 0 deg C, 10 min

3: H₂ / 10percent Pd/C / ethanol / 16 h / 23 °C

With hydrogen; sodium hexamethyldisilazane; diisobutylaluminium hydride; palladium on activated charcoal; In ethanol; toluene;
DOI:10.1021/jm980068d