tert-butyl [(1R,2R)-2-[methyl[[1-[((R)-1-(2,2,2-trifluoroacetyl)pyrrolidin-2-yl)methyl]-1H-1,2,3-triazol-4-yl]methyl]amino]cyclohexyl]carbamate

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Chemical Name:tert-butyl [(1R,2R)-2-[methyl[[1-[((R)-1-(2,2,2-trifluoroacetyl)pyrrolidin-2-yl)methyl]-1H-1,2,3-triazol-4-yl]methyl]amino]cyclohexyl]carbamate
CAS No.:1229407-68-4
Molecular Formula:C₂₂H₃₅F₃N₆O₃
Molecular Weight:488.554
Hs Code.:

Synonyms:tert-butyl [(1R,2R)-2-[methyl[[1-[((R)-1-(2,2,2-trifluoroacetyl)pyrrolidin-2-yl)methyl]-1H-1,2,3-triazol-4-yl]methyl]amino]cyclohexyl]carbamate

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Chemical Property of tert-butyl [(1R,2R)-2-[methyl[[1-[((R)-1-(2,2,2-trifluoroacetyl)pyrrolidin-2-yl)methyl]-1H-1,2,3-triazol-4-yl]methyl]amino]cyclohexyl]carbamate

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Technology Process of tert-butyl [(1R,2R)-2-[methyl[[1-[((R)-1-(2,2,2-trifluoroacetyl)pyrrolidin-2-yl)methyl]-1H-1,2,3-triazol-4-yl]methyl]amino]cyclohexyl]carbamate

There total 5 articles about tert-butyl [(1R,2R)-2-[methyl[[1-[((R)-1-(2,2,2-trifluoroacetyl)pyrrolidin-2-yl)methyl]-1H-1,2,3-triazol-4-yl]methyl]amino]cyclohexyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1229407-43-5
(R)-1-(2-(azidomethyl)-1-pyrrolidinyl)-2,2,2-trifluoroethanone

: 1229407-36-6
tert-butyl (1R,2R)-2-(methyl-(2-propynyl)amino)cyclohexylcarbamate

: 1229407-68-4
tert-butyl [(1R,2R)-2-[methyl[[1-[((R)-1-(2,2,2-trifluoroacetyl)pyrrolidin-2-yl)methyl]-1H-1,2,3-triazol-4-yl]methyl]amino]cyclohexyl]carbamate

Guidance literature:: With copper(II) sulfate; ascorbic acid sodium salt; In water; tert-butyl alcohol; at 20 ℃; regioselective reaction;
DOI:10.1016/j.tetlet.2010.03.053

Reference yield:

: C₁₄H₁₆F₃NO₄S

: 1229407-68-4
tert-butyl [(1R,2R)-2-[methyl[[1-[((R)-1-(2,2,2-trifluoroacetyl)pyrrolidin-2-yl)methyl]-1H-1,2,3-triazol-4-yl]methyl]amino]cyclohexyl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide; sodium iodide / 1,4-dioxane; dimethyl sulfoxide / 80 °C / Inert atmosphere

2: copper(II) sulfate; sodium L-ascorbate / water; tert-butyl alcohol / 20 °C / Inert atmosphere

With sodium azide; copper(II) sulfate; sodium L-ascorbate; sodium iodide; In 1,4-dioxane; water; dimethyl sulfoxide; tert-butyl alcohol; 2: Huisgen reaction;
DOI:10.3390/molecules15118327

Reference yield:

: 1229407-35-5
(R,R)-N-propargyl-N’-tert-butoxycarbonyl-1,2-diaminocyclohexane

: 1229407-68-4
tert-butyl [(1R,2R)-2-[methyl[[1-[((R)-1-(2,2,2-trifluoroacetyl)pyrrolidin-2-yl)methyl]-1H-1,2,3-triazol-4-yl]methyl]amino]cyclohexyl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; acetonitrile / 1 h / 20 °C / Inert atmosphere

1.2: 4 h / 20 °C / Inert atmosphere

2.1: copper(II) sulfate; sodium L-ascorbate / water; tert-butyl alcohol / 20 °C / Inert atmosphere

With copper(II) sulfate; sodium L-ascorbate; In water; acetonitrile; tert-butyl alcohol; 2.1: Huisgen reaction;
DOI:10.3390/molecules15118327