benzhydryl (2S)-2-amino-3-(thiazol-4-yl)propanoate p-toluenesulfonate

Base Information

• Chemical Name: benzhydryl (2S)-2-amino-3-(thiazol-4-yl)propanoate p-toluenesulfonate
• CAS No.: 204387-40-6
• Molecular Formula: C₇H₈O₃S*C₁₉H₁₈N₂O₂S
• Molecular Weight: 510.635
• Mol file: 204387-40-6.mol

Synonyms:benzhydryl (2S)-2-amino-3-(thiazol-4-yl)propanoate p-toluenesulfonate

Chemical Property of benzhydryl (2S)-2-amino-3-(thiazol-4-yl)propanoate p-toluenesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzhydryl (2S)-2-amino-3-(thiazol-4-yl)propanoate p-toluenesulfonate

There total 2 articles about benzhydryl (2S)-2-amino-3-(thiazol-4-yl)propanoate p-toluenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S)-2-amino-3-(thiazol-4-yl)propanoic acid p-toluenesulfonate (204387-38-2) + diazodiphenylmethane (908093-98-1) → benzhydryl (2S)-2-amino-3-(thiazol-4-yl)propanoate p-toluenesulfonate (204387-40-6)

Guidance literature:

With acetic acid; In ethanol (200 ml)-THF;

Reference yield:

(2S)-2-amino-3-(thiazol-4-yl)propanoic acid (119433-80-6,131896-42-9) + toluene-4-sulfonic acid (104-15-4) → benzhydryl (2S)-2-amino-3-(thiazol-4-yl)propanoate p-toluenesulfonate (204387-40-6)

Guidance literature:

Multi-step reaction with 2 steps

1: water

2: methanol / 1 h / 0 °C

In methanol; water;

DOI:10.1002/psc.3228

Reference yield:

benzhydryl (2S)-2-amino-3-(thiazol-4-yl)propanoate p-toluenesulfonate (204387-40-6) + (4R,5S)-5-methyl-2-oxooxazolidine-4-carboxylic acid (122871-70-9) → C24H23N3O5S

Guidance literature:

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1002/psc.3228

upstream raw materials:

(2S)-2-amino-3-(thiazol-4-yl)propanoic acid p-toluenesulfonate

diazodiphenylmethane

(2S)-2-amino-3-(thiazol-4-yl)propanoic acid

toluene-4-sulfonic acid

Downstream raw materials:

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