N-(3-(pyridin-3-ylamino)-5-(1-(triisopropylsilyl)-1H-indol-4-yl)phenyl)acetamide

Base Information

Chemical Name:N-(3-(pyridin-3-ylamino)-5-(1-(triisopropylsilyl)-1H-indol-4-yl)phenyl)acetamide
CAS No.:915413-01-3
Molecular Formula:C₃₀H₃₈N₄OSi
Molecular Weight:498.743
Hs Code.:

Synonyms:N-(3-(pyridin-3-ylamino)-5-(1-(triisopropylsilyl)-1H-indol-4-yl)phenyl)acetamide

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Chemical Property of N-(3-(pyridin-3-ylamino)-5-(1-(triisopropylsilyl)-1H-indol-4-yl)phenyl)acetamide

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Technology Process of N-(3-(pyridin-3-ylamino)-5-(1-(triisopropylsilyl)-1H-indol-4-yl)phenyl)acetamide

There total 5 articles about N-(3-(pyridin-3-ylamino)-5-(1-(triisopropylsilyl)-1H-indol-4-yl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 915412-99-6
N-(3-bromo-5-(pyridin-3-ylamino)phenyl)acetamide

: 388116-27-6
indole-4-boronic acid pinacol ester

: N-(3-(1H-indol-4-yl)-5-(pyridin-3-ylamino)phenyl)acetamide

: 915413-01-3
N-(3-(pyridin-3-ylamino)-5-(1-(triisopropylsilyl)-1H-indol-4-yl)phenyl)acetamide

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammomium bromide; In ethanol; water; toluene; at 110 ℃; for 18h;

Reference yield:

: 915412-99-6
N-(3-bromo-5-(pyridin-3-ylamino)phenyl)acetamide

: 690632-17-8
4-(4,4,5,5-tetramethyl-1,3,2-dioxoborolan-2-yl)-1-(triisopropylsilyl)-1H-indole

: N-(3-(1H-indol-4-yl)-5-(pyridin-3-ylamino)phenyl)acetamide

: 915413-01-3
N-(3-(pyridin-3-ylamino)-5-(1-(triisopropylsilyl)-1H-indol-4-yl)phenyl)acetamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammomium bromide; sodium carbonate; In ethanol; water; toluene; at 110 ℃; for 18h; Inert atmosphere;
DOI:10.1021/jm100659v

Reference yield:

: 462-08-8
pyridin-3-ylamine

: N-(3-(1H-indol-4-yl)-5-(pyridin-3-ylamino)phenyl)acetamide

: 915413-01-3
N-(3-(pyridin-3-ylamino)-5-(1-(triisopropylsilyl)-1H-indol-4-yl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate / 1,4-dioxane / 23 h / 110 °C / Inert atmosphere

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 4.75 h / 20 - 110 °C / Inert atmosphere

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammomium bromide; sodium carbonate / ethanol; water; toluene / 18 h / 110 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammomium bromide; sodium carbonate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; In 1,4-dioxane; ethanol; water; toluene; 1: Buchwald-Hartwig amination / 3: Suzuki coupling;
DOI:10.1021/jm100659v