3-iodo-benzoic acid 2,4-diamino-quinazolin-6-ylmethyl ester

Base Information

• Chemical Name: 3-iodo-benzoic acid 2,4-diamino-quinazolin-6-ylmethyl ester
• CAS No.: 454439-45-3
• Molecular Formula: C₁₆H₁₃IN₄O₂
• Molecular Weight: 420.209
• Mol file: 454439-45-3.mol

Synonyms:3-iodo-benzoic acid 2,4-diamino-quinazolin-6-ylmethyl ester

Chemical Property of 3-iodo-benzoic acid 2,4-diamino-quinazolin-6-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-iodo-benzoic acid 2,4-diamino-quinazolin-6-ylmethyl ester

There total 1 articles about 3-iodo-benzoic acid 2,4-diamino-quinazolin-6-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

6-(bromomethyl)-2,4-diaminoquinazoline + 3-Iodobenzoic acid (618-51-9) → 3-iodo-benzoic acid 2,4-diamino-quinazolin-6-ylmethyl ester (454439-45-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

DOI:10.1016/j.ejps.2004.02.004

Reference yield: 40.0%

(2,6-dimethoxyphenyl)boronic acid (23112-96-1) + 3-iodo-benzoic acid 2,4-diamino-quinazolin-6-ylmethyl ester (454439-45-3) → 2',6'-dimethoxy-biphenyl-3-carboxylic acid 2,4-diamino-quinazolin-6-ylmethyl ester

Guidance literature:

With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide; at 140 ℃; for 0.0333333h; microwave irradiation;

DOI:10.1016/j.ejps.2004.02.004

upstream raw materials:

3-Iodobenzoic acid