N-(2-Methoxyphenyl)-4-piperidone ethylene ketal

Base Information

• Chemical Name: N-(2-Methoxyphenyl)-4-piperidone ethylene ketal
• CAS No.: 218610-30-1
• Molecular Formula: C₁₄H₁₉NO₃
• Molecular Weight: 249.31
• Mol file: 218610-30-1.mol

Synonyms:N-(2-Methoxyphenyl)-4-piperidone ethylene ketal

Chemical Property of N-(2-Methoxyphenyl)-4-piperidone ethylene ketal

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-Methoxyphenyl)-4-piperidone ethylene ketal

There total 1 articles about N-(2-Methoxyphenyl)-4-piperidone ethylene ketal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromoanisole (578-57-4) + 4,4-ethylenedioxy-piperidine (177-11-7) + tris-(o-tolyl)phosphine (6163-58-2) → N-(2-Methoxyphenyl)-4-piperidone ethylene ketal (218610-30-1)

Guidance literature:

With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In toluene;

Reference yield:

N-(2-Methoxyphenyl)-4-piperidone ethylene ketal (218610-30-1) → N-(2'-methoxyphenyl)-4-piperidone (218610-31-2)

Guidance literature:

With hydrogenchloride; In water; acetic acid;

Reference yield:

N-(2-Methoxyphenyl)-4-piperidone ethylene ketal (218610-30-1) → N1-(1-(2-Methoxyphenyl)piperidin-4-yl)ethane-1,2-diamine (218610-33-4)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride / water; acetic acid

2: sodium cyanoborohydride; acetic acid / methanol; dichloromethane

With hydrogenchloride; sodium cyanoborohydride; acetic acid; In methanol; dichloromethane; water; acetic acid;

upstream raw materials:

2-bromoanisole

4,4-ethylenedioxy-piperidine

tris-(o-tolyl)phosphine

Downstream raw materials:

N-(2'-methoxyphenyl)-4-piperidone

N₁-(1-(2-Methoxyphenyl)piperidin-4-yl)ethane-1,2-diamine

(2-(1-(2-Methoxyphenyl)piperidin-4-ylamino)-ethyl)carbamic acid tert-butyl ester