(2R)-2-[(S)-hydroxy(phenyl)methyl]hex-5-ynoic acid

Base Information Edit

Chemical Name:(2R)-2-[(S)-hydroxy(phenyl)methyl]hex-5-ynoic acid
CAS No.:1190391-62-8
Molecular Formula:C₁₃H₁₄O₃
Molecular Weight:218.252
Hs Code.:
Mol file:1190391-62-8.mol

Synonyms:(2R)-2-[(S)-hydroxy(phenyl)methyl]hex-5-ynoic acid

Suppliers and Price of (2R)-2-[(S)-hydroxy(phenyl)methyl]hex-5-ynoic acid

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R)-2-[(S)-hydroxy(phenyl)methyl]hex-5-ynoic acid Edit

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R)-2-[(S)-hydroxy(phenyl)methyl]hex-5-ynoic acid

There total 4 articles about (2R)-2-[(S)-hydroxy(phenyl)methyl]hex-5-ynoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1190391-61-7
(4S)-3-{(2R)-2-[(S)-hydroxy(phenyl)methyl]hex-5-ynoyl}-4-phenyl-1,3-oxazolidin-2-one

: 1190391-62-8
(2R)-2-[(S)-hydroxy(phenyl)methyl]hex-5-ynoic acid

Guidance literature:: (4S)-3-{(2R)-2-[(S)-hydroxy(phenyl)methyl]hex-5-ynoyl}-4-phenyl-1,3-oxazolidin-2-one; With dihydrogen peroxide; lithium hydroxide; In tetrahydrofuran; water; at 0 - 5 ℃; for 3h; Inert atmosphere;

With sodium sulfite; In tetrahydrofuran; water; at 0 - 5 ℃;

With hydrogenchloride; In water; at 0 ℃; pH=3;

Reference yield:

: 53293-00-8
hex-5-ynoic acid

: 1190391-62-8
(2R)-2-[(S)-hydroxy(phenyl)methyl]hex-5-ynoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; pivaloyl chloride / tetrahydrofuran / 2.33 h / -25 °C / Inert atmosphere

1.2: 12 h / 20 °C / Cooling; Inert atmosphere

2.1: chloro-trimethyl-silane; triethylamine; magnesium chloride / ethyl acetate / 72 h / 20 °C / Inert atmosphere

2.2: 5 h / 20 °C / Inert atmosphere

3.1: lithium hydroxide; dihydrogen peroxide / water; tetrahydrofuran / 3 h / 0 - 5 °C / Inert atmosphere

3.2: 0 - 5 °C

3.3: 0 °C / pH 3

With chloro-trimethyl-silane; dihydrogen peroxide; pivaloyl chloride; triethylamine; magnesium chloride; lithium hydroxide; In tetrahydrofuran; water; ethyl acetate;

Reference yield:

: 1190391-59-3
(S)-3-(hex-5-ynoyl)-4-phenyloxazolidin-2-one

: 1190391-62-8
(2R)-2-[(S)-hydroxy(phenyl)methyl]hex-5-ynoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: chloro-trimethyl-silane; triethylamine; magnesium chloride / ethyl acetate / 72 h / 20 °C / Inert atmosphere

1.2: 5 h / 20 °C / Inert atmosphere

2.1: lithium hydroxide; dihydrogen peroxide / water; tetrahydrofuran / 3 h / 0 - 5 °C / Inert atmosphere

2.2: 0 - 5 °C

2.3: 0 °C / pH 3

With chloro-trimethyl-silane; dihydrogen peroxide; triethylamine; magnesium chloride; lithium hydroxide; In tetrahydrofuran; water; ethyl acetate;