(4R,5S)-carbonic acid [4-(benzyl(methyl)amino)-7-oxo-4',5'-dihydropyrazolo[1,5-c][1,3]-oxazin-5-yl]methyl tert-butyl ester

Base Information

Chemical Name:(4R,5S)-carbonic acid [4-(benzyl(methyl)amino)-7-oxo-4',5'-dihydropyrazolo[1,5-c][1,3]-oxazin-5-yl]methyl tert-butyl ester
CAS No.:1291072-29-1
Molecular Formula:C₂₀H₂₅N₃O₅
Molecular Weight:387.436
Hs Code.:

Synonyms:(4R,5S)-carbonic acid [4-(benzyl(methyl)amino)-7-oxo-4',5'-dihydropyrazolo[1,5-c][1,3]-oxazin-5-yl]methyl tert-butyl ester

Suppliers and Price of (4R,5S)-carbonic acid [4-(benzyl(methyl)amino)-7-oxo-4',5'-dihydropyrazolo[1,5-c][1,3]-oxazin-5-yl]methyl tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4R,5S)-carbonic acid [4-(benzyl(methyl)amino)-7-oxo-4',5'-dihydropyrazolo[1,5-c][1,3]-oxazin-5-yl]methyl tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4R,5S)-carbonic acid [4-(benzyl(methyl)amino)-7-oxo-4',5'-dihydropyrazolo[1,5-c][1,3]-oxazin-5-yl]methyl tert-butyl ester

There total 3 articles about (4R,5S)-carbonic acid [4-(benzyl(methyl)amino)-7-oxo-4',5'-dihydropyrazolo[1,5-c][1,3]-oxazin-5-yl]methyl tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1291072-19-9
(2S,3R)-3-(benzyl(methyl)amino)-3-(2H-pyrazol-3-yl)propane-1,2-diol

: 1291072-29-1
(4R,5S)-carbonic acid [4-(benzyl(methyl)amino)-7-oxo-4',5'-dihydropyrazolo[1,5-c][1,3]-oxazin-5-yl]methyl tert-butyl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1055/s-0030-1258326

Reference yield:

: 227622-58-4
(3S,4′S)-2-benzyl-3-(2′,2′-dimethyl-1′,3′-dioxolan-4′-yl)-4-methoxy-3,6-dihydro-2H-1,2-oxazine

: 1291072-29-1
(4R,5S)-carbonic acid [4-(benzyl(methyl)amino)-7-oxo-4',5'-dihydropyrazolo[1,5-c][1,3]-oxazin-5-yl]methyl tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetonitrile / 6 h / 0 - 20 °C / Inert atmosphere

1.2: 1 h / 0 °C / Inert atmosphere

2.1: hydrazine hydrate; trifluoroacetic acid / ethanol / 2 h / Reflux; Inert atmosphere

3.1: acetic acid / 2 h / Reflux; Inert atmosphere

4.1: dmap; triethylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere

With dmap; hydrazine hydrate; acetic acid; triethylamine; trifluoroacetic acid; In ethanol; dichloromethane; acetonitrile;
DOI:10.1055/s-0030-1258326

Reference yield:

: (4S,4'S)-4-(benzyl(methyl)amino)-4-(2',2'-dimethyl-1,3-dioxolan-4'-yl)-3-methoxybut-2-enal

: 1291072-29-1
(4R,5S)-carbonic acid [4-(benzyl(methyl)amino)-7-oxo-4',5'-dihydropyrazolo[1,5-c][1,3]-oxazin-5-yl]methyl tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate; trifluoroacetic acid / ethanol / 2 h / Reflux; Inert atmosphere

2: acetic acid / 2 h / Reflux; Inert atmosphere

3: dmap; triethylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere

With dmap; hydrazine hydrate; acetic acid; triethylamine; trifluoroacetic acid; In ethanol; dichloromethane;
DOI:10.1055/s-0030-1258326