(E)-(4-{methyl[(1-methyl-5-nitro-2-pyrrolyl)methyl]-amino}methyl)cinnamic acid trifluoroacetate

Base Information

• Chemical Name: (E)-(4-{methyl[(1-methyl-5-nitro-2-pyrrolyl)methyl]-amino}methyl)cinnamic acid trifluoroacetate
• CAS No.: 1017279-00-3
• Molecular Formula: C₂HF₃O₂*C₁₇H₁₉N₃O₄
• Molecular Weight: 443.38
• Mol file: 1017279-00-3.mol

Synonyms:(E)-(4-{methyl[(1-methyl-5-nitro-2-pyrrolyl)methyl]-amino}methyl)cinnamic acid trifluoroacetate

Chemical Property of (E)-(4-{methyl[(1-methyl-5-nitro-2-pyrrolyl)methyl]-amino}methyl)cinnamic acid trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-(4-{methyl[(1-methyl-5-nitro-2-pyrrolyl)methyl]-amino}methyl)cinnamic acid trifluoroacetate

There total 6 articles about (E)-(4-{methyl[(1-methyl-5-nitro-2-pyrrolyl)methyl]-amino}methyl)cinnamic acid trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl (E)-(4-{methyl[(1-methyl-5-nitro-2-pyrrolyl)methyl]amino}methyl)cinnamate (1017278-98-6) + trifluoroacetic acid (76-05-1) → (E)-(4-{methyl[(1-methyl-5-nitro-2-pyrrolyl)methyl]-amino}methyl)cinnamic acid trifluoroacetate (1017279-00-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2011.12.007

Reference yield:

2-(bromomethyl)-1-methyl-5-nitro-1H-pyrrole (1017279-01-4) → (E)-(4-{methyl[(1-methyl-5-nitro-2-pyrrolyl)methyl]-amino}methyl)cinnamic acid trifluoroacetate (1017279-00-3)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 15 h / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;

DOI:10.1016/j.bmc.2011.12.007

Reference yield:

(E)-tert-butyl 3-(4-(bromomethyl)phenyl)acrylate (1017278-96-4) → (E)-(4-{methyl[(1-methyl-5-nitro-2-pyrrolyl)methyl]-amino}methyl)cinnamic acid trifluoroacetate (1017279-00-3)

Guidance literature:

Multi-step reaction with 3 steps

1: ethanol; dichloromethane; water / 2 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 15 h / 20 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; water;

DOI:10.1016/j.bmc.2011.12.007

upstream raw materials:

2-(bromomethyl)-1-methyl-5-nitro-1H-pyrrole

(E)-tert-butyl 3-(4-(bromomethyl)phenyl)acrylate

tert-butyl (E)-(4-{methyl[(1-methyl-5-nitro-2-pyrrolyl)methyl]amino}methyl)cinnamate

trifluoroacetic acid

Downstream raw materials:

5-[bis(tert-butoxycarbonyl)]amino-1-(chloromethyl)-3-{(E)-3-[4-({methyl[(1-methyl-5-nitro-2-pyrrolyl)methyl]amino}methyl)phenyl]-2-propenoyl}-1,2-dihydro-3H-benzo[e]indole

C₁₇H₁₈ClN₃O₃