(S)-N-((2,4-dimethylphenyl)(phenyl)methyl)-2-(2-isonicotinoylbenzofuran-5-yl)acetamide

Base Information

Chemical Name:(S)-N-((2,4-dimethylphenyl)(phenyl)methyl)-2-(2-isonicotinoylbenzofuran-5-yl)acetamide
CAS No.:1422053-25-5
Molecular Formula:C₃₁H₂₆N₂O₃
Molecular Weight:474.559
Hs Code.:

Synonyms:(S)-N-((2,4-dimethylphenyl)(phenyl)methyl)-2-(2-isonicotinoylbenzofuran-5-yl)acetamide

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Chemical Property of (S)-N-((2,4-dimethylphenyl)(phenyl)methyl)-2-(2-isonicotinoylbenzofuran-5-yl)acetamide

Chemical Property:

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Technology Process of (S)-N-((2,4-dimethylphenyl)(phenyl)methyl)-2-(2-isonicotinoylbenzofuran-5-yl)acetamide

There total 8 articles about (S)-N-((2,4-dimethylphenyl)(phenyl)methyl)-2-(2-isonicotinoylbenzofuran-5-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1421949-18-9
2-(2-isonicotinoylbenzofuran-5-yl)acetic acid

: 1421949-27-0
2-(2-(hydroxy(pyridin-4-yl)methyl)benzofuran-5-yl)acetic acid

: 1421949-54-3
(S)-(2,4-dimethylphenyl)(phenyl)methanamine

: 1422053-25-5
(S)-N-((2,4-dimethylphenyl)(phenyl)methyl)-2-(2-isonicotinoylbenzofuran-5-yl)acetamide

: N-((S)-(2,4-dimethylphenyl)(phenyl)methyl)-2-(2-(hydroxy(pyridin-4-yl)methyl)benzofuran-5-yl)acetamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h; Overall yield = 98.8 %; Overall yield = 500 mg;

Reference yield:

: 1421949-02-1
methyl 2-(3-(2,2-dibromovinyl)-4-hydroxyphenyl)acetate

: 1422053-25-5
(S)-N-((2,4-dimethylphenyl)(phenyl)methyl)-2-(2-isonicotinoylbenzofuran-5-yl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper(l) iodide; potassium phosphate / tetrahydrofuran / 12 h / 80 °C / Inert atmosphere

2.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / 0 °C

2.2: 2 h

3.1: sodium hydroxide; water / methanol / 8 h / 20 °C

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 °C

With potassium phosphate; copper(l) iodide; water; isopropylmagnesium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 1421949-03-2
methyl 2-(2-bromobenzofuran-5-yl)acetate

: 1422053-25-5
(S)-N-((2,4-dimethylphenyl)(phenyl)methyl)-2-(2-isonicotinoylbenzofuran-5-yl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / 0 °C

1.2: 2 h

2.1: sodium hydroxide; water / methanol / 8 h / 20 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 °C

With water; isopropylmagnesium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;