(1'E)-16α-(2'-Benzyloxyethenyl)-3-methoxy-14,17α-ethenoestra-1,3,5(10)-trien-17β-yl acetate

Base Information

Chemical Name:(1'E)-16α-(2'-Benzyloxyethenyl)-3-methoxy-14,17α-ethenoestra-1,3,5(10)-trien-17β-yl acetate
CAS No.:330432-62-7
Molecular Formula:C₃₂H₃₆O₄
Molecular Weight:484.635
Hs Code.:

Synonyms:(1'E)-16α-(2'-Benzyloxyethenyl)-3-methoxy-14,17α-ethenoestra-1,3,5(10)-trien-17β-yl acetate

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Chemical Property of (1'E)-16α-(2'-Benzyloxyethenyl)-3-methoxy-14,17α-ethenoestra-1,3,5(10)-trien-17β-yl acetate

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Technology Process of (1'E)-16α-(2'-Benzyloxyethenyl)-3-methoxy-14,17α-ethenoestra-1,3,5(10)-trien-17β-yl acetate

There total 1 articles about (1'E)-16α-(2'-Benzyloxyethenyl)-3-methoxy-14,17α-ethenoestra-1,3,5(10)-trien-17β-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 75772-01-9
[(benzyloxy)methyl](triphenyl)phosphonium chloride

: 130535-89-6
17β-acetoxy-3-methoxy-14,17α-ethenooestra-1,3,5(10)-triene-16α-carbaldahyde

: 330432-63-8
(1'Z)-16α-(2'-Benzyloxyethenyl)-3-methoxy-14,17α-ethenoestra-1,3,5(10)-trien-17β-yl acetate

: 330432-62-7
(1'E)-16α-(2'-Benzyloxyethenyl)-3-methoxy-14,17α-ethenoestra-1,3,5(10)-trien-17β-yl acetate

Guidance literature:: [(benzyloxy)methyl](triphenyl)phosphonium chloride; With tert.-butyl lithium; In tetrahydrofuran; pentane; at 0 ℃; for 1h;

17β-acetoxy-3-methoxy-14,17α-ethenooestra-1,3,5(10)-triene-16α-carbaldahyde; In tetrahydrofuran; dichloromethane; at 25 ℃; for 3h; Further stages.;
DOI:10.1039/b005129m

Reference yield: 85.0%

: 330432-62-7
(1'E)-16α-(2'-Benzyloxyethenyl)-3-methoxy-14,17α-ethenoestra-1,3,5(10)-trien-17β-yl acetate

: 330432-64-9
(1'E)-16α-(2'-Benzyloxyethenyl)-3-methoxy-14,17α-ethenoestra-1,3,5(10)-trien-17β-ol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 25 ℃; for 0.333333h;
DOI:10.1039/b005129m

Reference yield:

: 330432-62-7
(1'E)-16α-(2'-Benzyloxyethenyl)-3-methoxy-14,17α-ethenoestra-1,3,5(10)-trien-17β-yl acetate

: 3'β-Benzyloxy-3-methoxy-3',6'-dihydro-15αH-benzo[14,15]-14β-estra-1,3,5(10)-trien-17-one

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / LAH / tetrahydrofuran / 0.33 h / 25 °C

2: 79 percent / KH / tetrahydrofuran / 1 h / Heating

With lithium aluminium tetrahydride; potassium hydride; In tetrahydrofuran; 2: anionic oxo-Cope rearrangement;
DOI:10.1039/b005129m