(S)-methyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-(4‘-cyano-2‘-((S)-pent-4-en-2-yloxy)-[1,1‘-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate

Base Information

• Chemical Name: (S)-methyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-(4‘-cyano-2‘-((S)-pent-4-en-2-yloxy)-[1,1‘-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate
• CAS No.: 1567219-40-2
• Molecular Formula: C₄₁H₄₉N₅O₅
• Molecular Weight: 691.871
• Mol file: 1567219-40-2.mol

Synonyms:(S)-methyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-(4‘-cyano-2‘-((S)-pent-4-en-2-yloxy)-[1,1‘-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate

Chemical Property of (S)-methyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-(4‘-cyano-2‘-((S)-pent-4-en-2-yloxy)-[1,1‘-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-methyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-(4‘-cyano-2‘-((S)-pent-4-en-2-yloxy)-[1,1‘-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate

There total 14 articles about (S)-methyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-(4‘-cyano-2‘-((S)-pent-4-en-2-yloxy)-[1,1‘-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

(S)-methyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-(3-bromophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate (1567215-32-0) + (S)-4-bromo-3-(pent-4-en-2-yloxy)benzonitrile (1567219-38-8) → (S)-methyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-(4‘-cyano-2‘-((S)-pent-4-en-2-yloxy)-[1,1‘-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate (1567219-40-2)

Guidance literature:

(S)-4-bromo-3-(pent-4-en-2-yloxy)benzonitrile; With zinc; In tetrahydrofuran; at 60 ℃; for 2h;

(S)-methyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-(3-bromophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate; In tetrahydrofuran; at 60 ℃; for 18h;

Reference yield:

methyl 2-(2-(3-bromophenyl)-7-hydroxy-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)acetate (1567213-35-7) → (S)-methyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-(4‘-cyano-2‘-((S)-pent-4-en-2-yloxy)-[1,1‘-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate (1567219-40-2)

Guidance literature:

Multi-step reaction with 6 steps

1.1: N,N-dimethyl-aniline; trichlorophosphate / 2.5 h / 120 °C

2.1: potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C

2.2: 2.16 h / -78 °C

2.3: 1 h / 20 °C

3.1: (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; benzo[1,3,2]dioxaborole / toluene / 2.66 h / -35 - -15 °C

3.2: 0.17 h

4.1: perchloric acid / dichloromethane / 3 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 21 h / 20 - 50 °C / Inert atmosphere

6.1: zinc / tetrahydrofuran / 2 h / 60 °C

6.2: 18 h / 60 °C

With perchloric acid; potassium hexamethylsilazane; N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; zinc; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; trichlorophosphate; benzo[1,3,2]dioxaborole; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

methyl 2-(2-(3-bromophenyl)-7-chloro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)acetate (1567213-38-0) → (S)-methyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-(4‘-cyano-2‘-((S)-pent-4-en-2-yloxy)-[1,1‘-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate (1567219-40-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C

1.2: 2.16 h / -78 °C

1.3: 1 h / 20 °C

2.1: (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; benzo[1,3,2]dioxaborole / toluene / 2.66 h / -35 - -15 °C

2.2: 0.17 h

3.1: perchloric acid / dichloromethane / 3 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 21 h / 20 - 50 °C / Inert atmosphere

5.1: zinc / tetrahydrofuran / 2 h / 60 °C

5.2: 18 h / 60 °C

With perchloric acid; potassium hexamethylsilazane; N-ethyl-N,N-diisopropylamine; zinc; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; benzo[1,3,2]dioxaborole; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;

upstream raw materials:

methyl 2-(2-(3-bromophenyl)-7-hydroxy-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)acetate

methyl 2-(2-(3-bromophenyl)-7-chloro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)acetate

methyl 2-(2-(3-bromophenyl)-7-chloro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-oxoacetate

(S)-methyl 2-(2-(3-bromophenyl)-7-chloro-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-hydroxyacetate