Technology Process of 15,16-Dimethoxy-cis-erythrinan-2,8-dion-2-ethylenacetal
There total 1 articles about 15,16-Dimethoxy-cis-erythrinan-2,8-dion-2-ethylenacetal which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 97 percent / LiBH4 / tetrahydrofuran / 24 h / 20 °C
2: 63 percent / toluene / 48 h / Heating
3: 92 percent / TiCl4 / CH2Cl2 / 20 h / -78 °C
4: 93 percent / Dess-Martin periodinane / CH2Cl2
5: 6 percent / dppp; mesitylene / Rh(PPh3)2(CO)Cl / 96 h / Heating
6: pTSA / toluene / Heating
With
lithium borohydride; 1,3-bis-(diphenylphosphino)propane; titanium tetrachloride; Dess-Martin periodane; toluene-4-sulfonic acid; 1,3,5-trimethyl-benzene;
chlorocarbonylbis(triphenylphosphine)rhodium(I);
In
tetrahydrofuran; dichloromethane; toluene;
DOI:10.1016/j.tetlet.2004.05.060
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 99 percent / acetone / p-toluenesulfonic acid / 3 h / Heating
2.1: 99 percent / NaBH4 / methanol / 0.5 h
3.1: 86 percent / imidazole / dimethylformamide / 1 h / 20 °C
4.1: lithium diisopropylamide / tetrahydrofuran; hexane / 0.5 h / -78 °C
4.2: tetrahydrofuran; hexane / 0.58 h / -78 - 20 °C
With
1H-imidazole; sodium tetrahydroborate; acetone; lithium diisopropyl amide;
toluene-4-sulfonic acid;
In
tetrahydrofuran; methanol; hexane; N,N-dimethyl-formamide;
DOI:10.1021/ol0607185
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: 99 percent / acetone / p-toluenesulfonic acid / 3 h / Heating
2.1: 99 percent / NaBH4 / methanol / 0.5 h
3.1: 86 percent / imidazole / dimethylformamide / 1 h / 20 °C
4.1: lithium diisopropylamide / tetrahydrofuran; hexane / 0.5 h / -78 °C
4.2: tetrahydrofuran; hexane / 0.58 h / -78 - 20 °C
5.1: 604 mg / NaIO4 / methanol; H2O / 1 h / 20 °C
6.1: TBAF / tetrahydrofuran / 5 h / 20 °C
7.1: Et3N / CH2Cl2 / 1 h
8.1: 356 mg / DBU / tetrahydrofuran / 3 h / Heating
9.1: 31 percent / selenium dioxide; formic acid / dioxane / 96 h / Heating
10.1: 91 percent / NaOH; tetraethylammonium bromide / tetrahydrofuran / 36 h / 20 °C
With
1H-imidazole; sodium hydroxide; sodium tetrahydroborate; sodium periodate; formic acid; selenium(IV) oxide; tetraethylammonium bromide; tetrabutyl ammonium fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; acetone; lithium diisopropyl amide;
toluene-4-sulfonic acid;
In
tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ol0607185
