5(S)-<(tert-butoxycarbonyl)amino>-6-phenyl-2(R)-(phenylmethyl)-1-<(2-tetrahydropyranyl)oxy>-trans-3-hexene

Base Information

Chemical Name:5(S)-<(tert-butoxycarbonyl)amino>-6-phenyl-2(R)-(phenylmethyl)-1-<(2-tetrahydropyranyl)oxy>-trans-3-hexene
CAS No.:108385-64-4
Molecular Formula:C₂₉H₃₉NO₄
Molecular Weight:465.633
Hs Code.:

Synonyms:5(S)-<(tert-butoxycarbonyl)amino>-6-phenyl-2(R)-(phenylmethyl)-1-<(2-tetrahydropyranyl)oxy>-trans-3-hexene

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Chemical Property of 5(S)-<(tert-butoxycarbonyl)amino>-6-phenyl-2(R)-(phenylmethyl)-1-<(2-tetrahydropyranyl)oxy>-trans-3-hexene

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Technology Process of 5(S)-<(tert-butoxycarbonyl)amino>-6-phenyl-2(R)-(phenylmethyl)-1-<(2-tetrahydropyranyl)oxy>-trans-3-hexene

There total 12 articles about 5(S)-<(tert-butoxycarbonyl)amino>-6-phenyl-2(R)-(phenylmethyl)-1-<(2-tetrahydropyranyl)oxy>-trans-3-hexene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 131915-24-7
[(1S,4S)-2-Benzenesulfonyl-1-benzyl-3-hydroxy-5-phenyl-4-(tetrahydro-pyran-2-yloxymethyl)-pentyl]-carbamic acid tert-butyl ester

: 108385-64-4
5(S)-<(tert-butoxycarbonyl)amino>-6-phenyl-2(R)-(phenylmethyl)-1-<(2-tetrahydropyranyl)oxy>-trans-3-hexene

Guidance literature:: With disodium hydrogenphosphate; sodium amalgam; In methanol; at 0 ℃; for 4h; Yield given;
DOI:10.1016/S0040-4039(00)84457-3

Reference yield:

: 109687-70-9
tert-butyl (S)-(1-phenyl-3-(phenylthio)propan-2-yl)carbamate

: 108385-64-4
5(S)-<(tert-butoxycarbonyl)amino>-6-phenyl-2(R)-(phenylmethyl)-1-<(2-tetrahydropyranyl)oxy>-trans-3-hexene

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / m-chloroperoxybenzoic acid / CH₂Cl₂ / 1 h / 25 °C

2: 1.) MeLi / 1.) THF, ether, -78 deg C, 0.5 h, 2.) THF, ether, -78 deg C, 0.25 h

3: 5percent Na(Hg) / methanol / 4 h / 0 °C

With sodium amalgam; methyllithium; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane;
DOI:10.1021/jo00226a007

Reference yield:

: 109687-76-5
4-methyl-2(R)-(phenylmethyl)-3-penten-1-ol

: 108385-64-4
5(S)-<(tert-butoxycarbonyl)amino>-6-phenyl-2(R)-(phenylmethyl)-1-<(2-tetrahydropyranyl)oxy>-trans-3-hexene

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / piridinium p-toluenosulfonate / CH₂Cl₂ / 3 h / 25 °C

2: 1.) ozone, 2.) Me₂S / 1.) CH₂Cl₂, MeOH, -78 deg C, 5 min

3: 1.) MeLi / 1.) THF, ether, -78 deg C, 0.5 h, 2.) THF, ether, -78 deg C, 0.25 h

4: 5percent Na(Hg) / methanol / 4 h / 0 °C

With sodium amalgam; dimethylsulfide; methyllithium; pyridinium p-toluenesulfonate; ozone; In methanol; dichloromethane;
DOI:10.1021/jo00226a007