1-(N-tert-butyloxycarbonyl-L-valyl-N_ε-methyloxycarbonyl-L-lysyl-L-leucyl)-2-(4-hydroxybenzyl) hydrazine

Base Information

• Chemical Name: 1-(N-tert-butyloxycarbonyl-L-valyl-N_ε-methyloxycarbonyl-L-lysyl-L-leucyl)-2-(4-hydroxybenzyl) hydrazine
• CAS No.: 150651-01-7
• Molecular Formula: C₃₁H₅₂N₆O₈
• Molecular Weight: 636.789

Synonyms:1-(N-tert-butyloxycarbonyl-L-valyl-N_ε-methyloxycarbonyl-L-lysyl-L-leucyl)-2-(4-hydroxybenzyl) hydrazine

Chemical Property of 1-(N-tert-butyloxycarbonyl-L-valyl-N_ε-methyloxycarbonyl-L-lysyl-L-leucyl)-2-(4-hydroxybenzyl) hydrazine

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 1-(N-tert-butyloxycarbonyl-L-valyl-N_ε-methyloxycarbonyl-L-lysyl-L-leucyl)-2-(4-hydroxybenzyl) hydrazine

There total 8 articles about 1-(N-tert-butyloxycarbonyl-L-valyl-N_ε-methyloxycarbonyl-L-lysyl-L-leucyl)-2-(4-hydroxybenzyl) hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butoxycarbonylvalyl-Nε-benzyloxycarbonyllysine (68455-55-0) → 1-(N-tert-butyloxycarbonyl-L-valyl-Nε-methyloxycarbonyl-L-lysyl-L-leucyl)-2-(4-hydroxybenzyl) hydrazine (150651-01-7)

Guidance literature:

Multi-step reaction with 7 steps

1: N-methylmorpholine / tetrahydrofuran / 0.5 h / -15 °C

2: tetrahydrofuran / 2 h / -15 °C

3: 100 percent / H₂ / 10percent Pd/C / tetrahydrofuran / 3 h

4: 70 percent / 1 M aq. NaHCO₃ / CHCl₃ / 0.5 h / Ambient temperature

5: 100 percent / hydrazine hydrate / ethanol / 60 h / Ambient temperature

6: 100 percent / acetic acid / 12 h / Ambient temperature

7: 1.) NaBH₃CN, AcOH, 2.) 2N aq. NaCO₃ / 1.) THF, RT, overnight, 2.) MeOH, RT, 4 h

With 4-methyl-morpholine; hydrogen; sodium cyanoborohydride; sodium hydrogencarbonate; hydrazine hydrate; acetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; chloroform; acetic acid;

DOI:10.1016/0223-5234(93)90147-7

Reference yield:

methyl (L)-leucinate hydrochloride (7517-19-3) → 1-(N-tert-butyloxycarbonyl-L-valyl-Nε-methyloxycarbonyl-L-lysyl-L-leucyl)-2-(4-hydroxybenzyl) hydrazine (150651-01-7)

Guidance literature:

Multi-step reaction with 6 steps

1: tetrahydrofuran / 2 h / -15 °C

2: 100 percent / H₂ / 10percent Pd/C / tetrahydrofuran / 3 h

3: 70 percent / 1 M aq. NaHCO₃ / CHCl₃ / 0.5 h / Ambient temperature

4: 100 percent / hydrazine hydrate / ethanol / 60 h / Ambient temperature

5: 100 percent / acetic acid / 12 h / Ambient temperature

6: 1.) NaBH₃CN, AcOH, 2.) 2N aq. NaCO₃ / 1.) THF, RT, overnight, 2.) MeOH, RT, 4 h

With hydrogen; sodium cyanoborohydride; sodium hydrogencarbonate; hydrazine hydrate; acetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; chloroform; acetic acid;

DOI:10.1016/0223-5234(93)90147-7

Reference yield:

N-tert-butyloxycarbonyl-L-valyl-Nε-benzyloxycarbonyl-L-lysyl-L-leucine methylester (150650-93-4) → 1-(N-tert-butyloxycarbonyl-L-valyl-Nε-methyloxycarbonyl-L-lysyl-L-leucyl)-2-(4-hydroxybenzyl) hydrazine (150651-01-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 100 percent / H₂ / 10percent Pd/C / tetrahydrofuran / 3 h

2: 70 percent / 1 M aq. NaHCO₃ / CHCl₃ / 0.5 h / Ambient temperature

3: 100 percent / hydrazine hydrate / ethanol / 60 h / Ambient temperature

4: 100 percent / acetic acid / 12 h / Ambient temperature

5: 1.) NaBH₃CN, AcOH, 2.) 2N aq. NaCO₃ / 1.) THF, RT, overnight, 2.) MeOH, RT, 4 h

With hydrogen; sodium cyanoborohydride; sodium hydrogencarbonate; hydrazine hydrate; acetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; chloroform; acetic acid;

DOI:10.1016/0223-5234(93)90147-7

upstream raw materials:

1-(N-tert-butyloxycarbonyl-L-valyl-N_ε-methyloxycarbonyl-L-lysyl-L-leucyl)-2-(4-hydroxybenzal) hydrazone

tert-butoxycarbonylvalyl-N^ε-benzyloxycarbonyllysine

methyl (L)-leucinate hydrochloride

N-tert-butyloxycarbonyl-L-valyl-L-lysyl-L-leucine methylester

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