[(1S)-1-[[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-2-pyrrolidinyl]-1H-imidazol-5-yl]-1,3-butadiynyl]phenyl]-1H-imidazol-2-yl]-1-pyrrolidinyl]carbonyl]-2-methylpropyl]carbamic acid methyl ester

Base Information

Chemical Name:[(1S)-1-[[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-2-pyrrolidinyl]-1H-imidazol-5-yl]-1,3-butadiynyl]phenyl]-1H-imidazol-2-yl]-1-pyrrolidinyl]carbonyl]-2-methylpropyl]carbamic acid methyl ester
CAS No.:1380293-06-0
Molecular Formula:C₃₈H₄₆N₈O₆
Molecular Weight:710.833
Hs Code.:

[(1S)-1-[[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-2-pyrrolidinyl]-1H-imidazol-5-yl]-1,3-butadiynyl]phenyl]-1H-imidazol-2-yl]-1-pyrrolidinyl]carbonyl]-2-methylpropyl]carbamic acid methyl ester

Synonyms:[(1S)-1-[[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-2-pyrrolidinyl]-1H-imidazol-5-yl]-1,3-butadiynyl]phenyl]-1H-imidazol-2-yl]-1-pyrrolidinyl]carbonyl]-2-methylpropyl]carbamic acid methyl ester

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Chemical Property of [(1S)-1-[[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-2-pyrrolidinyl]-1H-imidazol-5-yl]-1,3-butadiynyl]phenyl]-1H-imidazol-2-yl]-1-pyrrolidinyl]carbonyl]-2-methylpropyl]carbamic acid methyl ester

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Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of [(1S)-1-[[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-2-pyrrolidinyl]-1H-imidazol-5-yl]-1,3-butadiynyl]phenyl]-1H-imidazol-2-yl]-1-pyrrolidinyl]carbonyl]-2-methylpropyl]carbamic acid methyl ester

There total 5 articles about [(1S)-1-[[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-2-pyrrolidinyl]-1H-imidazol-5-yl]-1,3-butadiynyl]phenyl]-1H-imidazol-2-yl]-1-pyrrolidinyl]carbonyl]-2-methylpropyl]carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1380290-34-5
2-[(2S)-pyrrolidin-2-yl]-5-[4-(4-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-5-yl}buta-1,3-diyn-1-yl)phenyl]-1H-imidazole

: 111398-44-8,74761-42-5
N-methoxycarbonyl-L-valine

: 1380293-06-0
[(1S)-1-[[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-2-pyrrolidinyl]-1H-imidazol-5-yl]-1,3-butadiynyl]phenyl]-1H-imidazol-2-yl]-1-pyrrolidinyl]carbonyl]-2-methylpropyl]carbamic acid methyl ester

Guidance literature:: N-methoxycarbonyl-L-valine; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; for 1h;

2-[(2S)-pyrrolidin-2-yl]-5-[4-(4-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-5-yl}buta-1,3-diyn-1-yl)phenyl]-1H-imidazole; With diisopropylamine; In acetonitrile; at 20 ℃; for 12h;

Reference yield:

: 1242094-29-6
tert-butyl (S)-2-[5-(4-iodophenyl)-1H-imidazol-2-yl]pyrrolidine-1-carboxylate

: 1380293-06-0
[(1S)-1-[[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-2-pyrrolidinyl]-1H-imidazol-5-yl]-1,3-butadiynyl]phenyl]-1H-imidazol-2-yl]-1-pyrrolidinyl]carbonyl]-2-methylpropyl]carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: methyllithium lithium bromide / diethyl ether / 20 °C / Inert atmosphere

1.2: 12 h / 40 °C / Inert atmosphere

2.1: potassium carbonate; methanol / tetrahydrofuran / 2 h

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenylphosphine; copper(l) iodide / tetrahydrofuran / 12 h / 40 °C / Inert atmosphere

4.1: hydrogenchloride / 1,4-dioxane / 12 h

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 1 h

5.2: 12 h / 20 °C

With hydrogenchloride; methanol; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; methyllithium lithium bromide; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; acetonitrile;

Reference yield:

: 1380290-30-1
tert-butyl (2S)-2-(5-{4-[4-(trimethylsilyl)buta-1,3-diyn-1-yl]phenyl}-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

: 1380293-06-0
[(1S)-1-[[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-2-pyrrolidinyl]-1H-imidazol-5-yl]-1,3-butadiynyl]phenyl]-1H-imidazol-2-yl]-1-pyrrolidinyl]carbonyl]-2-methylpropyl]carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate; methanol / tetrahydrofuran / 2 h

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenylphosphine; copper(l) iodide / tetrahydrofuran / 12 h / 40 °C / Inert atmosphere

3.1: hydrogenchloride / 1,4-dioxane / 12 h

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 1 h

4.2: 12 h / 20 °C

With hydrogenchloride; methanol; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; acetonitrile;