(1S,4R,5R,6S)-4,5,6-Tris-methoxymethoxy-cyclohex-2-enol

Base Information

Chemical Name:(1S,4R,5R,6S)-4,5,6-Tris-methoxymethoxy-cyclohex-2-enol
CAS No.:351885-23-9
Molecular Formula:C₁₂H₂₂O₇
Molecular Weight:278.302
Hs Code.:

Synonyms:(1S,4R,5R,6S)-4,5,6-Tris-methoxymethoxy-cyclohex-2-enol

Suppliers and Price of (1S,4R,5R,6S)-4,5,6-Tris-methoxymethoxy-cyclohex-2-enol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,4R,5R,6S)-4,5,6-Tris-methoxymethoxy-cyclohex-2-enol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (1S,4R,5R,6S)-4,5,6-Tris-methoxymethoxy-cyclohex-2-enol

There total 11 articles about (1S,4R,5R,6S)-4,5,6-Tris-methoxymethoxy-cyclohex-2-enol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 243987-96-4
(1R,2S,5S,7R)-7-(benzyloxymethyl)-6,8-dioxabicyclo[3.2.1]oct-3-en-2-ol

: 351885-23-9
(1S,4R,5R,6S)-4,5,6-Tris-methoxymethoxy-cyclohex-2-enol

Guidance literature:: Multi-step reaction with 10 steps

1: PPh₃; DIAD / tetrahydrofuran

2: 95 percent / OsO₄; NMO / tetrahydrofuran; H₂O

3: NH₄OH / methanol

4: 64 percent / Huenig base / CH₂Cl₂

5: 85 percent / H₂ / Pd/C / ethyl acetate

6: 81 percent / I₂; PPh₃; imidazole / tetrahydrofuran

7: 96 percent / Zn / acetic acid; methanol / 20 °C

8: 62 percent / LDA / tetrahydrofuran / -78 - 20 °C

9: H₂; quinoline / Pd/BaSO₄ / ethyl acetate

10: Grubbs' catalyst / benzene / Heating

With 1H-imidazole; quinoline; ammonium hydroxide; osmium(VIII) oxide; N-methyl-2-indolinone; di-isopropyl azodicarboxylate; hydrogen; iodine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; zinc; lithium diisopropyl amide; palladium on activated charcoal; Pd-BaSO₄; Grubbs catalyst first generation; In tetrahydrofuran; methanol; dichloromethane; water; acetic acid; ethyl acetate; benzene;
DOI:10.1021/ol015963x

Reference yield:

: (1S,5S,7R)-7-Benzyloxymethyl-6,8-dioxa-bicyclo[3.2.1]oct-3-en-2-one

: 351885-23-9
(1S,4R,5R,6S)-4,5,6-Tris-methoxymethoxy-cyclohex-2-enol

Guidance literature:: Multi-step reaction with 11 steps

1: 90 percent / NaBH₄; CeCl₃ / 0 °C

2: PPh₃; DIAD / tetrahydrofuran

3: 95 percent / OsO₄; NMO / tetrahydrofuran; H₂O

4: NH₄OH / methanol

5: 64 percent / Huenig base / CH₂Cl₂

6: 85 percent / H₂ / Pd/C / ethyl acetate

7: 81 percent / I₂; PPh₃; imidazole / tetrahydrofuran

8: 96 percent / Zn / acetic acid; methanol / 20 °C

9: 62 percent / LDA / tetrahydrofuran / -78 - 20 °C

10: H₂; quinoline / Pd/BaSO₄ / ethyl acetate

11: Grubbs' catalyst / benzene / Heating

With 1H-imidazole; quinoline; ammonium hydroxide; sodium tetrahydroborate; osmium(VIII) oxide; N-methyl-2-indolinone; cerium(III) chloride; di-isopropyl azodicarboxylate; hydrogen; iodine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; zinc; lithium diisopropyl amide; palladium on activated charcoal; Pd-BaSO₄; Grubbs catalyst first generation; In tetrahydrofuran; methanol; dichloromethane; water; acetic acid; ethyl acetate; benzene;
DOI:10.1021/ol015963x

Reference yield:

: (3S,4S,5S,6S)-3,4,5-Tris-methoxymethoxy-6-vinyl-tetrahydro-pyran-2-ol

: 351885-23-9
(1S,4R,5R,6S)-4,5,6-Tris-methoxymethoxy-cyclohex-2-enol

Guidance literature:: Multi-step reaction with 3 steps

1: 62 percent / LDA / tetrahydrofuran / -78 - 20 °C

2: H₂; quinoline / Pd/BaSO₄ / ethyl acetate

3: Grubbs' catalyst / benzene / Heating

With quinoline; hydrogen; lithium diisopropyl amide; Pd-BaSO₄; Grubbs catalyst first generation; In tetrahydrofuran; ethyl acetate; benzene;
DOI:10.1021/ol015963x