(2R)-2-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)propanoylchloride

Base Information

• Chemical Name: (2R)-2-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)propanoylchloride
• CAS No.: 53100-40-6
• Molecular Formula: C₁₁H₈ClNO₃
• Molecular Weight: 237.642
• Mol file: 53100-40-6.mol

Synonyms:(2R)-2-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)propanoylchloride

Chemical Property of (2R)-2-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)propanoylchloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-2-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)propanoylchloride

There total 2 articles about (2R)-2-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)propanoylchloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-phthalyl-L-alanine (4192-28-3,19506-87-7,21860-84-4,29588-83-8) → L-2-methyl-2-(phthalimido)acetyl chlorid (4306-25-6,5364-22-7,53100-40-6,53701-47-6)

Guidance literature:

With thionyl chloride; Yield given;

DOI:10.1007/BF00959578

Reference yield:

phthalic anhydride (85-44-9) → L-2-methyl-2-(phthalimido)acetyl chlorid (4306-25-6,5364-22-7,53100-40-6,53701-47-6)

Guidance literature:

Multi-step reaction with 2 steps

2: SOCl₂

With thionyl chloride;

DOI:10.1007/BF00959578

Reference yield: 80.0%

(+/-)-trans-4,5-diphenyl-pyrrolidin-2-one + (2R)-2-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)propanoylchloride (53100-40-6) → 2-[1(R)-methyl-2-oxo-2-(5-oxo-2(S),3(R)-diphenyl-pyrrolidin-1-yl)-ethyl]-isoindole-1,3-dione (548488-27-3) + 2-[(R)-1-Methyl-2-oxo-2-((2R,3S)-5-oxo-2,3-diphenyl-pyrrolidin-1-yl)-ethyl]-isoindole-1,3-dione

Guidance literature:

(+/-)-trans-4,5-diphenyl-pyrrolidin-2-one; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 0.416667h;

(2R)-2-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)propanoylchloride; In tetrahydrofuran; hexane; at 20 ℃; for 1h;

DOI:10.1016/S0957-4166(03)00097-1

upstream raw materials:

N-phthalyl-L-alanine

phthalic anhydride

Downstream raw materials:

N-((R)-1-methyl-2-oxo-2-phenyl-ethyl)-phthalimide

(R)-Mesityl-(1-phthalimidoethyl)-keton

(R)-(+)-2-N-phthalimidopropanal

2-[1(R)-methyl-2-oxo-2-(5-oxo-2(S),3(R)-diphenyl-pyrrolidin-1-yl)-ethyl]-isoindole-1,3-dione