1-(3'-amino-5'-O-benzyl-2'-O-tert-butyldimethylsilyl-3'-C-cyano-3'-deoxy-3'-N-phenylmethanesulfonyl-β-D-ribofuranosyl)-3-N-tert-butoxycarbonylthymine

Base Information

• Chemical Name: 1-(3'-amino-5'-O-benzyl-2'-O-tert-butyldimethylsilyl-3'-C-cyano-3'-deoxy-3'-N-phenylmethanesulfonyl-β-D-ribofuranosyl)-3-N-tert-butoxycarbonylthymine
• CAS No.: 1035648-42-0
• Molecular Formula: C₃₆H₄₈N₄O₉SSi
• Molecular Weight: 740.95

Synonyms:1-(3'-amino-5'-O-benzyl-2'-O-tert-butyldimethylsilyl-3'-C-cyano-3'-deoxy-3'-N-phenylmethanesulfonyl-β-D-ribofuranosyl)-3-N-tert-butoxycarbonylthymine

Chemical Property of 1-(3'-amino-5'-O-benzyl-2'-O-tert-butyldimethylsilyl-3'-C-cyano-3'-deoxy-3'-N-phenylmethanesulfonyl-β-D-ribofuranosyl)-3-N-tert-butoxycarbonylthymine

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Technology Process of 1-(3'-amino-5'-O-benzyl-2'-O-tert-butyldimethylsilyl-3'-C-cyano-3'-deoxy-3'-N-phenylmethanesulfonyl-β-D-ribofuranosyl)-3-N-tert-butoxycarbonylthymine

There total 1 articles about 1-(3'-amino-5'-O-benzyl-2'-O-tert-butyldimethylsilyl-3'-C-cyano-3'-deoxy-3'-N-phenylmethanesulfonyl-β-D-ribofuranosyl)-3-N-tert-butoxycarbonylthymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

1-(3'-amino-5'-O-benzyl-2'-O-tert-butyldimethylsilyl-3'-C-cyano-3'-deoxy-3'-N-phenylmethanesulfonyl-β-D-ribofuranosyl)thymine (1035648-40-8) + di-tert-butyl dicarbonate (24424-99-5) → 1-(3'-amino-5'-O-benzyl-2'-O-tert-butyldimethylsilyl-3'-C-cyano-3'-deoxy-3'-N-phenylmethanesulfonyl-β-D-ribofuranosyl)-3-N-tert-butoxycarbonylthymine (1035648-42-0)

Guidance literature:

In pyridine; dichloromethane; at 20 ℃; for 15h;

DOI:10.1016/j.bmc.2008.02.026

Reference yield: 76.0%

1-(3'-amino-5'-O-benzyl-2'-O-tert-butyldimethylsilyl-3'-C-cyano-3'-deoxy-3'-N-phenylmethanesulfonyl-β-D-ribofuranosyl)-3-N-tert-butoxycarbonylthymine (1035648-42-0) → [1-[5'-O-benzyl-2'-O-tert-butyldimethylsilyl-β-D-ribofuranosyl]-3-N-tert-butoxycarbonylthymine]-3'-spiro-3''-(2''-H-4''-amino-2'',3''-dihydro-1'',1''-dioxo-isothiazole-5''-phenyl) (1035648-44-2)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.25h;

DOI:10.1016/j.bmc.2008.02.026

upstream raw materials:

1-(3'-amino-5'-O-benzyl-2'-O-tert-butyldimethylsilyl-3'-C-cyano-3'-deoxy-3'-N-phenylmethanesulfonyl-β-D-ribofuranosyl)thymine

di-tert-butyl dicarbonate

Downstream raw materials:

[1-[5'-O-benzyl-2'-O-tert-butyldimethylsilyl-β-D-ribofuranosyl]-3-N-tert-butoxycarbonylthymine]-3'-spiro-3''-(2''-H-4''-amino-2'',3''-dihydro-1'',1''-dioxo-isothiazole-5''-phenyl)

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