(R)-3-(benzyloxy)-3-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,2-dimethylpropyl acetate

Base Information

Chemical Name:(R)-3-(benzyloxy)-3-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,2-dimethylpropyl acetate
CAS No.:1377411-61-4
Molecular Formula:C₁₉H₂₈O₅
Molecular Weight:336.428
Hs Code.:

Synonyms:(R)-3-(benzyloxy)-3-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,2-dimethylpropyl acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-3-(benzyloxy)-3-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,2-dimethylpropyl acetate

Chemical Property:

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Technology Process of (R)-3-(benzyloxy)-3-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,2-dimethylpropyl acetate

There total 4 articles about (R)-3-(benzyloxy)-3-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,2-dimethylpropyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 895532-69-1
(R)-3-(benzyloxy)-3-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,2-dimethylpropan-1-ol

: 108-24-7
acetic anhydride

: 1377411-61-4
(R)-3-(benzyloxy)-3-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,2-dimethylpropyl acetate

Guidance literature:: (R)-3-(benzyloxy)-3-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,2-dimethylpropan-1-ol; With dmap; triethylamine; In dichloromethane; at 0 ℃;

acetic anhydride; In dichloromethane; at 20 ℃;
DOI:10.1055/s-0031-1290489

Reference yield:

: ethyl 3-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-3-hydroxy-2,2-dimethylpropanoate

: 1377411-61-4
(R)-3-(benzyloxy)-3-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,2-dimethylpropyl acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: Dess-Martin periodane / dichloromethane / 4 h / 20 °C

2.1: sodium tetrahydroborate / methanol / 1 h / -40 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C

3.2: 20 °C

4.1: lithium aluminium tetrahydride / diethyl ether / 0 °C

5.1: dmap; triethylamine / dichloromethane / 0 °C

5.2: 20 °C

With dmap; sodium tetrahydroborate; lithium aluminium tetrahydride; sodium hydride; Dess-Martin periodane; triethylamine; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1055/s-0031-1290489

Reference yield:

: 1377411-50-1
ethyl (R)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyl-3-oxopropanoate

: 1377411-61-4
(R)-3-(benzyloxy)-3-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,2-dimethylpropyl acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium tetrahydroborate / methanol / 1 h / -40 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C

2.2: 20 °C

3.1: lithium aluminium tetrahydride / diethyl ether / 0 °C

4.1: dmap; triethylamine / dichloromethane / 0 °C

4.2: 20 °C

With dmap; sodium tetrahydroborate; lithium aluminium tetrahydride; sodium hydride; triethylamine; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1055/s-0031-1290489