2-(S)-hydroxy-3-(4-tetrahydropyranyloxy-3-methylphenyl)propan-1-ol trityl ether

Base Information

• Chemical Name: 2-(S)-hydroxy-3-(4-tetrahydropyranyloxy-3-methylphenyl)propan-1-ol trityl ether
• CAS No.: 443147-14-6
• Molecular Formula: C₃₄H₃₆O₄
• Molecular Weight: 508.657
• Mol file: 443147-14-6.mol

Synonyms:2-(S)-hydroxy-3-(4-tetrahydropyranyloxy-3-methylphenyl)propan-1-ol trityl ether

Chemical Property of 2-(S)-hydroxy-3-(4-tetrahydropyranyloxy-3-methylphenyl)propan-1-ol trityl ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(S)-hydroxy-3-(4-tetrahydropyranyloxy-3-methylphenyl)propan-1-ol trityl ether

There total 1 articles about 2-(S)-hydroxy-3-(4-tetrahydropyranyloxy-3-methylphenyl)propan-1-ol trityl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-bromo-2-methyl-1-(2'-tetrahydropyranyloxy)benzene (148344-51-8) + (S)-tritylglycidol (129940-50-7) → 2-(S)-hydroxy-3-(4-tetrahydropyranyloxy-3-methylphenyl)propan-1-ol trityl ether (443147-14-6)

Guidance literature:

4-bromo-2-methyl-1-(2'-tetrahydropyranyloxy)benzene; With copper(l) iodide; magnesium; In tetrahydrofuran; at 0 ℃;

(S)-tritylglycidol; In tetrahydrofuran;

DOI:10.1016/S0968-0896(02)00031-7

Reference yield:

2-(S)-hydroxy-3-(4-tetrahydropyranyloxy-3-methylphenyl)propan-1-ol trityl ether (443147-14-6) → 2-(S)-hydroxy-3-(4-hydroxy-3-methylphenyl)propan-1-ol

Guidance literature:

With water; acetic acid; In tetrahydrofuran; at 65 ℃;

DOI:10.1016/S0968-0896(02)00031-7

Reference yield:

2-(S)-hydroxy-3-(4-tetrahydropyranyloxy-3-methylphenyl)propan-1-ol trityl ether (443147-14-6) → 3-(S)-hydroxy-4-(4-hydroxy-3-methylphenyl)-1-butyne (443147-28-2)

Guidance literature:

Multi-step reaction with 8 steps

1: AcOH; H₂O / tetrahydrofuran / 65 °C

2: 2,4,6-collidine / CH₂Cl₂ / -78 °C

3: p-TsOH*H₂O / CH₂Cl₂ / 20 °C

4: 51 percent / 2N NaOH / methanol / 20 °C

5: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -70 - -30 °C

6: PPh₃; Et₃N / CH₂Cl₂ / -40 °C

7: n-BuLi / tetrahydrofuran; hexane / -70 °C

8: 85 percent / p-TsOH*H₂O / methanol / 20 °C

With 2,4,6-trimethyl-pyridine; sodium hydroxide; n-butyllithium; oxalyl dichloride; water; toluene-4-sulfonic acid; acetic acid; dimethyl sulfoxide; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; hexane; dichloromethane;

DOI:10.1016/S0968-0896(02)00031-7

upstream raw materials:

4-bromo-2-methyl-1-(2'-tetrahydropyranyloxy)benzene

(S)-tritylglycidol

Downstream raw materials:

3-(S)-hydroxy-4-(4-hydroxy-3-methylphenyl)-1-butyne

2-(S)-tetrahydropyranyloxy-3-(4-tetrahydropyranyloxy-3-methylphenyl)propan-1-al

3-(S)-tetrahydropyranyloxy-4-(4-tetrahydropyranyloxy-3-methylphenyl)-1-butyne

2-(S)-tetrahydropyranyloxy-3-(4-tetrahydropyranyloxy-3-methylphenyl)propan-1-ol