2-(S)-hydroxy-3-(4-tetrahydropyranyloxy-3-methylphenyl)propan-1-ol trityl ether

Base Information

Chemical Name:2-(S)-hydroxy-3-(4-tetrahydropyranyloxy-3-methylphenyl)propan-1-ol trityl ether
CAS No.:443147-14-6
Molecular Formula:C₃₄H₃₆O₄
Molecular Weight:508.657
Hs Code.:

Synonyms:2-(S)-hydroxy-3-(4-tetrahydropyranyloxy-3-methylphenyl)propan-1-ol trityl ether

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Chemical Property of 2-(S)-hydroxy-3-(4-tetrahydropyranyloxy-3-methylphenyl)propan-1-ol trityl ether

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Technology Process of 2-(S)-hydroxy-3-(4-tetrahydropyranyloxy-3-methylphenyl)propan-1-ol trityl ether

There total 1 articles about 2-(S)-hydroxy-3-(4-tetrahydropyranyloxy-3-methylphenyl)propan-1-ol trityl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 148344-51-8
4-bromo-2-methyl-1-(2'-tetrahydropyranyloxy)benzene

: 129940-50-7
(S)-tritylglycidol

: 443147-14-6
2-(S)-hydroxy-3-(4-tetrahydropyranyloxy-3-methylphenyl)propan-1-ol trityl ether

Guidance literature:: 4-bromo-2-methyl-1-(2'-tetrahydropyranyloxy)benzene; With copper(l) iodide; magnesium; In tetrahydrofuran; at 0 ℃;

(S)-tritylglycidol; In tetrahydrofuran;
DOI:10.1016/S0968-0896(02)00031-7

Reference yield:

: 443147-14-6
2-(S)-hydroxy-3-(4-tetrahydropyranyloxy-3-methylphenyl)propan-1-ol trityl ether

: 2-(S)-hydroxy-3-(4-hydroxy-3-methylphenyl)propan-1-ol

Guidance literature:: With water; acetic acid; In tetrahydrofuran; at 65 ℃;
DOI:10.1016/S0968-0896(02)00031-7

Reference yield:

: 443147-14-6
2-(S)-hydroxy-3-(4-tetrahydropyranyloxy-3-methylphenyl)propan-1-ol trityl ether

: 443147-28-2
3-(S)-hydroxy-4-(4-hydroxy-3-methylphenyl)-1-butyne

Guidance literature:: Multi-step reaction with 8 steps

1: AcOH; H₂O / tetrahydrofuran / 65 °C

2: 2,4,6-collidine / CH₂Cl₂ / -78 °C

3: p-TsOH*H₂O / CH₂Cl₂ / 20 °C

4: 51 percent / 2N NaOH / methanol / 20 °C

5: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -70 - -30 °C

6: PPh₃; Et₃N / CH₂Cl₂ / -40 °C

7: n-BuLi / tetrahydrofuran; hexane / -70 °C

8: 85 percent / p-TsOH*H₂O / methanol / 20 °C

With 2,4,6-trimethyl-pyridine; sodium hydroxide; n-butyllithium; oxalyl dichloride; water; toluene-4-sulfonic acid; acetic acid; dimethyl sulfoxide; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1016/S0968-0896(02)00031-7