[4-bromo-3-(trifluoromethoxy)phenyl](2-oxa-6-azaspiro[3.3]hept-6-yl)-methanone

Base Information

Chemical Name:[4-bromo-3-(trifluoromethoxy)phenyl](2-oxa-6-azaspiro[3.3]hept-6-yl)-methanone
CAS No.:1352621-31-8
Molecular Formula:C₁₃H₁₁BrF₃NO₃
Molecular Weight:366.134
Hs Code.:

Synonyms:[4-bromo-3-(trifluoromethoxy)phenyl](2-oxa-6-azaspiro[3.3]hept-6-yl)-methanone

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Chemical Property of [4-bromo-3-(trifluoromethoxy)phenyl](2-oxa-6-azaspiro[3.3]hept-6-yl)-methanone

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Technology Process of [4-bromo-3-(trifluoromethoxy)phenyl](2-oxa-6-azaspiro[3.3]hept-6-yl)-methanone

There total 4 articles about [4-bromo-3-(trifluoromethoxy)phenyl](2-oxa-6-azaspiro[3.3]hept-6-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1159599-99-1,1045709-32-7,1254966-66-9
2-oxa-6-azaspiro[3.3]heptan-6-ium carboxyformate

: 1008769-87-6
4-bromo-3-(trifluoromethoxy)benzoic acid

: 1352621-31-8
[4-bromo-3-(trifluoromethoxy)phenyl](2-oxa-6-azaspiro[3.3]hept-6-yl)-methanone

Guidance literature:: 4-bromo-3-(trifluoromethoxy)benzoic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In N,N-dimethyl-formamide; for 0.5h; Molecular sieve;

2-oxa-6-azaspiro[3.3]heptan-6-ium carboxyformate; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 17h;

Reference yield:

: 175278-22-5
4-amino-3-(trifluoromethoxy)benzoic acid

: 1352621-31-8
[4-bromo-3-(trifluoromethoxy)phenyl](2-oxa-6-azaspiro[3.3]hept-6-yl)-methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / 3 h / 0 °C / Reflux

2.1: sodium nitrite; hydrogen bromide / water / 0.17 h / 5 °C

2.2: 1.08 h

3.1: sodium hydroxide; ethanol / 2 h / 20 °C

3.2: pH 3

4.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.5 h / Molecular sieve

4.2: 17 h / 20 °C

With thionyl chloride; ethanol; hydrogen bromide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; sodium hydroxide; sodium nitrite; In water; N,N-dimethyl-formamide;

Reference yield:

: 1260742-02-6
ethyl 4-amino-3-(trifluoromethoxy)benzoate

: 1352621-31-8
[4-bromo-3-(trifluoromethoxy)phenyl](2-oxa-6-azaspiro[3.3]hept-6-yl)-methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium nitrite; hydrogen bromide / water / 0.17 h / 5 °C

1.2: 1.08 h

2.1: sodium hydroxide; ethanol / 2 h / 20 °C

2.2: pH 3

3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.5 h / Molecular sieve

3.2: 17 h / 20 °C

With ethanol; hydrogen bromide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; sodium hydroxide; sodium nitrite; In water; N,N-dimethyl-formamide;