[(R)-3-((R)-4-Benzhydryl-2-oxo-oxazolidin-3-yl)-2-benzyl-3-oxo-propyl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:[(R)-3-((R)-4-Benzhydryl-2-oxo-oxazolidin-3-yl)-2-benzyl-3-oxo-propyl]-carbamic acid tert-butyl ester
CAS No.:287719-27-1
Molecular Formula:C₃₁H₃₄N₂O₅
Molecular Weight:514.621
Hs Code.:

Synonyms:[(R)-3-((R)-4-Benzhydryl-2-oxo-oxazolidin-3-yl)-2-benzyl-3-oxo-propyl]-carbamic acid tert-butyl ester

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Chemical Property of [(R)-3-((R)-4-Benzhydryl-2-oxo-oxazolidin-3-yl)-2-benzyl-3-oxo-propyl]-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:: SDS file from LookChem

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Technology Process of [(R)-3-((R)-4-Benzhydryl-2-oxo-oxazolidin-3-yl)-2-benzyl-3-oxo-propyl]-carbamic acid tert-butyl ester

There total 6 articles about [(R)-3-((R)-4-Benzhydryl-2-oxo-oxazolidin-3-yl)-2-benzyl-3-oxo-propyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 287719-11-3
4-(4-benzhydryl-2-oxo-oxazolidin-3-yl)-4-oxo-butyric acid tert-butyl ester

: 287719-27-1
[(R)-3-((R)-4-Benzhydryl-2-oxo-oxazolidin-3-yl)-2-benzyl-3-oxo-propyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: NaHMDS / tetrahydrofuran / 0.33 h / -78 °C

1.2: 83 percent / tetrahydrofuran / 4 h / -78 - -48 °C

2.1: 93 percent / CF₃COOH / CH₂Cl₂ / 12 h / 20 °C

3.1: Et₃N / acetone / 0.25 h / 0 °C

4.1: aq. NaN₃ / acetone / 15 h / 0 °C

5.1: toluene / 1 h / Heating

6.1: toluene / 12 h / Heating

With sodium azide; sodium hexamethyldisilazane; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; acetone; toluene; 1.1: Metallation / 1.2: Alkylation / 2.1: Substitution / 3.1: Substitution / 4.1: Substitution / 5.1: Rearrangement / 6.1: Addition;
DOI:10.1039/a908747h

Reference yield:

: 287719-24-8
(R)-4-((R)-4-Benzhydryl-2-oxo-oxazolidin-3-yl)-3-benzyl-4-oxo-butyric acid

: 287719-27-1
[(R)-3-((R)-4-Benzhydryl-2-oxo-oxazolidin-3-yl)-2-benzyl-3-oxo-propyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / acetone / 0.25 h / 0 °C

2: aq. NaN₃ / acetone / 15 h / 0 °C

3: toluene / 1 h / Heating

4: toluene / 12 h / Heating

With sodium azide; triethylamine; In acetone; toluene; 1: Substitution / 2: Substitution / 3: Rearrangement / 4: Addition;
DOI:10.1039/a908747h

Reference yield:

: 287719-12-4
(R)-4-((R)-4-Benzhydryl-2-oxo-oxazolidin-3-yl)-3-benzyl-4-oxo-butyric acid tert-butyl ester

: 287719-27-1
[(R)-3-((R)-4-Benzhydryl-2-oxo-oxazolidin-3-yl)-2-benzyl-3-oxo-propyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / CF₃COOH / CH₂Cl₂ / 12 h / 20 °C

2: Et₃N / acetone / 0.25 h / 0 °C

3: aq. NaN₃ / acetone / 15 h / 0 °C

4: toluene / 1 h / Heating

5: toluene / 12 h / Heating

With sodium azide; triethylamine; trifluoroacetic acid; In dichloromethane; acetone; toluene; 1: Substitution / 2: Substitution / 3: Substitution / 4: Rearrangement / 5: Addition;
DOI:10.1039/a908747h