1-[2-(2-fluoro-4-nitro-phenoxy)-ethyl]-4-methyl-piperazine

Base Information

• Chemical Name: 1-[2-(2-fluoro-4-nitro-phenoxy)-ethyl]-4-methyl-piperazine
• CAS No.: 1015077-02-7
• Molecular Formula: C₁₃H₁₈FN₃O₃
• Molecular Weight: 283.303
• Mol file: 1015077-02-7.mol

Synonyms:1-[2-(2-fluoro-4-nitro-phenoxy)-ethyl]-4-methyl-piperazine

Chemical Property of 1-[2-(2-fluoro-4-nitro-phenoxy)-ethyl]-4-methyl-piperazine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 1-[2-(2-fluoro-4-nitro-phenoxy)-ethyl]-4-methyl-piperazine

There total 2 articles about 1-[2-(2-fluoro-4-nitro-phenoxy)-ethyl]-4-methyl-piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methyl-piperazine (109-01-3) + 2-(2-fluoro-4-nitrophenoxy)ethyl chloride (958231-86-2) → 1-[2-(2-fluoro-4-nitro-phenoxy)-ethyl]-4-methyl-piperazine (1015077-02-7)

Guidance literature:

With potassium carbonate; In acetonitrile; at 80 ℃;

DOI:10.1021/jm060435i

Reference yield:

2-fluoro-4-nitrophenol (403-19-0) → 1-[2-(2-fluoro-4-nitro-phenoxy)-ethyl]-4-methyl-piperazine (1015077-02-7)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / acetonitrile / Heating

2: K₂CO₃ / acetonitrile / 80 °C

With potassium carbonate; In acetonitrile;

DOI:10.1021/jm060435i

Reference yield:

1-[2-(2-fluoro-4-nitro-phenoxy)-ethyl]-4-methyl-piperazine (1015077-02-7) → 3-fluoro-4-(2-(4-methylpiperazin-1-yl)ethoxy)aniline (835633-63-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 16h;

DOI:10.1021/jm060435i

upstream raw materials:

1-methyl-piperazine

2-(2-fluoro-4-nitrophenoxy)ethyl chloride

2-fluoro-4-nitrophenol

Downstream raw materials:

3-fluoro-4-(2-(4-methylpiperazin-1-yl)ethoxy)aniline