tert-butyl {4-[2-(bis-(tert-butoxycarbonylmethyl)amino)-3-(4-nitrophenyl)propyl]-7-tert-butoxycarbonylmethyl[1,4,7]triazanonan-1-yl}acetate

Base Information

Chemical Name:tert-butyl {4-[2-(bis-(tert-butoxycarbonylmethyl)amino)-3-(4-nitrophenyl)propyl]-7-tert-butoxycarbonylmethyl[1,4,7]triazanonan-1-yl}acetate
CAS No.:1005484-26-3
Molecular Formula:C₃₉H₆₅N₅O₁₀
Molecular Weight:763.973
Hs Code.:

Synonyms:tert-butyl {4-[2-(bis-(tert-butoxycarbonylmethyl)amino)-3-(4-nitrophenyl)propyl]-7-tert-butoxycarbonylmethyl[1,4,7]triazanonan-1-yl}acetate

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Chemical Property of tert-butyl {4-[2-(bis-(tert-butoxycarbonylmethyl)amino)-3-(4-nitrophenyl)propyl]-7-tert-butoxycarbonylmethyl[1,4,7]triazanonan-1-yl}acetate

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Technology Process of tert-butyl {4-[2-(bis-(tert-butoxycarbonylmethyl)amino)-3-(4-nitrophenyl)propyl]-7-tert-butoxycarbonylmethyl[1,4,7]triazanonan-1-yl}acetate

There total 6 articles about tert-butyl {4-[2-(bis-(tert-butoxycarbonylmethyl)amino)-3-(4-nitrophenyl)propyl]-7-tert-butoxycarbonylmethyl[1,4,7]triazanonan-1-yl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1-(4-nitrophenyl)-3-(1,4,7-triazonan-1-yl)propan-2-amine tetrahydrochloride

: 5292-43-3
bromoacetic acid tert-butyl ester

: 1005484-26-3
tert-butyl {4-[2-(bis-(tert-butoxycarbonylmethyl)amino)-3-(4-nitrophenyl)propyl]-7-tert-butoxycarbonylmethyl[1,4,7]triazanonan-1-yl}acetate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; potassium iodide; In N,N-dimethyl-formamide; at 90 ℃; for 19h;
DOI:10.1021/jm070401q

Reference yield: 10.0%

: 1-(4-nitrophenyl)-3-(1,4,7-triazonan-1-yl)propan-2-amine tetrahydrochloride

: 5292-43-3
bromoacetic acid tert-butyl ester

: 1005484-26-3
tert-butyl {4-[2-(bis-(tert-butoxycarbonylmethyl)amino)-3-(4-nitrophenyl)propyl]-7-tert-butoxycarbonylmethyl[1,4,7]triazanonan-1-yl}acetate

: tert-butyl {4-tert-butoxycarbonylmethyl-7-[2-(tert-butoxycarbonylmethyl-amino)-3-(4-nitro-phenyl)-propyl]-[1,4,7]-triazonan-1-yl}-acetate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; sodium iodide; In N,N-dimethyl-formamide; at 60 - 70 ℃; for 20h;

Reference yield:

: 1258945-86-6
tert-butyl N-[1-(4-nitrophenyl)-3-oxopropan-2-yl]carbamate

: 1005484-26-3
tert-butyl {4-[2-(bis-(tert-butoxycarbonylmethyl)amino)-3-(4-nitrophenyl)propyl]-7-tert-butoxycarbonylmethyl[1,4,7]triazanonan-1-yl}acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,2-dichloro-ethane / 0.17 h / 0 °C

1.2: 0 - 20 °C

2.1: hydrogenchloride / 1,4-dioxane / 20 h / 20 °C

3.1: sodium iodide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 h / 60 - 70 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; sodium iodide; In 1,4-dioxane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;