((2-(4-(1-(2-tert-butoxycarbonylaminoethyl)-6-oxo-1,6-dihydropyridazin-3-yl)benzylamino)ethyl)-(5-chloro-1H-indole-2-sulfonyl)amino)acetic acid

Base Information

Chemical Name:((2-(4-(1-(2-tert-butoxycarbonylaminoethyl)-6-oxo-1,6-dihydropyridazin-3-yl)benzylamino)ethyl)-(5-chloro-1H-indole-2-sulfonyl)amino)acetic acid
CAS No.:919110-29-5
Molecular Formula:C₃₀H₃₅ClN₆O₇S
Molecular Weight:659.163
Hs Code.:

Synonyms:((2-(4-(1-(2-tert-butoxycarbonylaminoethyl)-6-oxo-1,6-dihydropyridazin-3-yl)benzylamino)ethyl)-(5-chloro-1H-indole-2-sulfonyl)amino)acetic acid

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Chemical Property of ((2-(4-(1-(2-tert-butoxycarbonylaminoethyl)-6-oxo-1,6-dihydropyridazin-3-yl)benzylamino)ethyl)-(5-chloro-1H-indole-2-sulfonyl)amino)acetic acid

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Technology Process of ((2-(4-(1-(2-tert-butoxycarbonylaminoethyl)-6-oxo-1,6-dihydropyridazin-3-yl)benzylamino)ethyl)-(5-chloro-1H-indole-2-sulfonyl)amino)acetic acid

There total 5 articles about ((2-(4-(1-(2-tert-butoxycarbonylaminoethyl)-6-oxo-1,6-dihydropyridazin-3-yl)benzylamino)ethyl)-(5-chloro-1H-indole-2-sulfonyl)amino)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 919110-23-9
(2-(3-chloro-6-oxo-6H-pyridazin-1-yl)ethyl)carbamic acid tert-butyl ester

: 919110-25-1
N-((5-chloro-1H-indol-2-yl)-sulfonyl)-N-(2-((4-dihydroxyborylbenzyl)amino)ethyl)glycine

: 919110-29-5
((2-(4-(1-(2-tert-butoxycarbonylaminoethyl)-6-oxo-1,6-dihydropyridazin-3-yl)benzylamino)ethyl)-(5-chloro-1H-indole-2-sulfonyl)amino)acetic acid

Guidance literature:: With caesium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; ethanol; water; at 150 ℃; for 0.0277778h;

Reference yield:

: 919110-17-1
4-(4-iodobenzyl)-3-oxopiperazine-1-carboxylic acid tert-butyl ester

: 919110-29-5
((2-(4-(1-(2-tert-butoxycarbonylaminoethyl)-6-oxo-1,6-dihydropyridazin-3-yl)benzylamino)ethyl)-(5-chloro-1H-indole-2-sulfonyl)amino)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 2 h / 100 °C

1.2: 0.5 h

2.1: triethylamine / water; N,N-dimethyl-formamide / 2 h / 0 - 20 °C

3.1: sodium hydroxide / water / 0.33 h / 80 °C

3.2: acid

4.1: caesium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; ethanol; water / 0.03 h / 150 °C

With sodium hydroxide; caesium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 919110-20-6
(4-(2-oxopiperazin-1-ylmethyl)-phenyl)boronic acid hydrochloride

: 919110-29-5
((2-(4-(1-(2-tert-butoxycarbonylaminoethyl)-6-oxo-1,6-dihydropyridazin-3-yl)benzylamino)ethyl)-(5-chloro-1H-indole-2-sulfonyl)amino)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / water; N,N-dimethyl-formamide / 2 h / 0 - 20 °C

2.1: sodium hydroxide / water / 0.33 h / 80 °C

2.2: acid

3.1: caesium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; ethanol; water / 0.03 h / 150 °C

With sodium hydroxide; caesium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide;