methyl (S,S,S)-2-[2-(1-{2-[1-(N-Boc)amino-2-methylpropyl]-thiazole-4-carbonylamino}-2-methylpropyl)thiazole-4-carbonyl]-(O-TBDPS)-L-threonate

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Chemical Name:methyl (S,S,S)-2-[2-(1-{2-[1-(N-Boc)amino-2-methylpropyl]-thiazole-4-carbonylamino}-2-methylpropyl)thiazole-4-carbonyl]-(O-TBDPS)-L-threonate
CAS No.:1033722-50-7
Molecular Formula:C₄₇H₆₆N₆O₈S₂Si
Molecular Weight:935.294
Hs Code.:

Synonyms:methyl (S,S,S)-2-[2-(1-{2-[1-(N-Boc)amino-2-methylpropyl]-thiazole-4-carbonylamino}-2-methylpropyl)thiazole-4-carbonyl]-(O-TBDPS)-L-threonate

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Chemical Property of methyl (S,S,S)-2-[2-(1-{2-[1-(N-Boc)amino-2-methylpropyl]-thiazole-4-carbonylamino}-2-methylpropyl)thiazole-4-carbonyl]-(O-TBDPS)-L-threonate

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Technology Process of methyl (S,S,S)-2-[2-(1-{2-[1-(N-Boc)amino-2-methylpropyl]-thiazole-4-carbonylamino}-2-methylpropyl)thiazole-4-carbonyl]-(O-TBDPS)-L-threonate

There total 1 articles about methyl (S,S,S)-2-[2-(1-{2-[1-(N-Boc)amino-2-methylpropyl]-thiazole-4-carbonylamino}-2-methylpropyl)thiazole-4-carbonyl]-(O-TBDPS)-L-threonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 867262-38-2
N-{2-[(S)-1-(N-tert-butyloxycarbonyl)amino-2-methylpropyl]thiazol-4-ylcarbonyl}-L-Val-(S)NH₂

: 1033722-45-0
N-(3-bromo-2-oxopropanoyl)-L-Val-L-Thr(O-TBDPS)-OMe

: 1033722-50-7
methyl (S,S,S)-2-[2-(1-{2-[1-(N-Boc)amino-2-methylpropyl]-thiazole-4-carbonylamino}-2-methylpropyl)thiazole-4-carbonyl]-(O-TBDPS)-L-threonate

Guidance literature:: N-{2-[(S)-1-(N-tert-butyloxycarbonyl)amino-2-methylpropyl]thiazol-4-ylcarbonyl}-L-Val-(S)NH₂; N-(3-bromo-2-oxopropanoyl)-L-Val-L-Thr(O-TBDPS)-OMe; With potassium carbonate; In 1,2-dimethoxyethane; at 0 - 20 ℃;

With pyridine; trifluoroacetic anhydride; In 1,2-dimethoxyethane; at 0 ℃; for 0.5h;

With ammonium hydroxide; In water; ethyl acetate; at 0 ℃; for 0.25h;
DOI:10.1246/bcsj.81.495