3'-methylbenzyl β-D-glucopyranosiduronic acid

Base Information

• Chemical Name: 3'-methylbenzyl β-D-glucopyranosiduronic acid
• CAS No.: 1020203-98-8
• Molecular Formula: C₁₄H₁₈O₇
• Molecular Weight: 298.293
• Mol file: 1020203-98-8.mol

Synonyms:3'-methylbenzyl β-D-glucopyranosiduronic acid

Chemical Property of 3'-methylbenzyl β-D-glucopyranosiduronic acid

Chemical Property:

Purity/Quality:

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Technology Process of 3'-methylbenzyl β-D-glucopyranosiduronic acid

There total 2 articles about 3'-methylbenzyl β-D-glucopyranosiduronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

1-deoxy-1-fluoro-α-D-glucopyranuronic acid ammonium salt + 3-methylbenzyl alcohol (587-03-1) → 3'-methylbenzyl β-D-glucopyranosiduronic acid (1020203-98-8)

Guidance literature:

With histidine-6 tagged glucuronylsynthase E₅₀₄G mutant from Escherichia coli strain GMS₄₀₇(DE₃); at 21 ℃; pH=7.5; aq. phosphate buffer; Enzymatic reaction;

DOI:10.1021/jo101914s

Reference yield:

1-deoxy-1-fluoro-α-D-glucose (2106-10-7) → 3'-methylbenzyl β-D-glucopyranosiduronic acid (1020203-98-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hypochlorite; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hydroxide / water / 3 h / 4 °C / pH 9.5

2: histidine-6 tagged glucuronylsynthase E₅₀₄G mutant from Escherichia coli strain GMS₄₀₇(DE₃) / 21 °C / pH 7.5 / aq. phosphate buffer; Enzymatic reaction

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; histidine-6 tagged glucuronylsynthase E₅₀₄G mutant from Escherichia coli strain GMS₄₀₇(DE₃); sodium hydroxide; In water;

DOI:10.1021/jo101914s

upstream raw materials:

3-methylbenzyl alcohol

1-deoxy-1-fluoro-α-D-glucose