MC₇₀

Base Information

• Chemical Name: MC₇₀
• CAS No.: 1031367-64-2
• Molecular Formula: C₂₄H₂₅NO₃
• Molecular Weight: 375.467
• Mol file: 1031367-64-2.mol

Synonyms:MC₇₀

Chemical Property of MC₇₀

Chemical Property:

Purity/Quality:

>98 % ^*data from raw suppliers

MC 70 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of MC₇₀

There total 7 articles about MC₇₀ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4’-((6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methyl)-4-biphenyl p-toluenesulfonate → MC70 (1031367-64-2)

Guidance literature:

With sodium hydroxide; In water; acetonitrile; at 80 ℃; for 6h;

DOI:10.1002/cmdc.201500538

Reference yield: 35.0%

C24H23NO4 (1031367-55-1) → MC70 (1031367-64-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h; Heating;

DOI:10.1016/j.bmc.2008.01.055

Reference yield:

4'-hydroxy-4-chloromethylbiphenyl + 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline monohydrochloride (2328-12-3) → MC70 (1031367-64-2)

Guidance literature:

With 4-methyl-morpholine; In acetonitrile; for 6h; Reflux;

DOI:10.3390/molecules23061401

upstream raw materials:

C₂₄H₂₃NO₄

4'-Hydroxybiphenyl-4-carboxylic acid

C₁₃H₉ClO₂

6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline monohydrochloride

Refernces

• 1、 Guglielmo, Stefano,Contino, Marialessandra,Lazzarato, Loretta,Perrone, Maria Grazia,Blangetti, Marco,Fruttero, Roberta,Colabufo, Nicola Antonio. "A Potent and Selective P-gp Modulator for Altering Multidrug Resistance Due to Pump Overexpression". . p. 374 - 376. Retrieved 2016.
• 2、 Savolainen, Heli,Cantore, Mariangela,Colabufo, Nicola A.,Elsinga, Philip H.,Windhorst, Albert D.,Luurtsema, Gert. "Synthesis and Preclinical Evaluation of Three Novel Fluorine-18 Labeled Radiopharmaceuticals for P-Glycoprotein PET Imaging at the Blood-Brain Barrier". . p. 2265 - 2275. Retrieved 2015/07/15.