[(1S,2R)-2-((2S,3R)-1-Benzyl-3-benzyloxy-4-oxo-azetidin-2-yl)-1-(tert-butyl-diphenyl-silanyloxymethyl)-2-methoxy-ethyl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:[(1S,2R)-2-((2S,3R)-1-Benzyl-3-benzyloxy-4-oxo-azetidin-2-yl)-1-(tert-butyl-diphenyl-silanyloxymethyl)-2-methoxy-ethyl]-carbamic acid tert-butyl ester
CAS No.:160527-49-1
Molecular Formula:C₄₂H₅₂N₂O₆Si
Molecular Weight:708.97
Hs Code.:

[(1S,2R)-2-((2S,3R)-1-Benzyl-3-benzyloxy-4-oxo-azetidin-2-yl)-1-(tert-butyl-diphenyl-silanyloxymethyl)-2-methoxy-ethyl]-carbamic acid tert-butyl ester

Synonyms:[(1S,2R)-2-((2S,3R)-1-Benzyl-3-benzyloxy-4-oxo-azetidin-2-yl)-1-(tert-butyl-diphenyl-silanyloxymethyl)-2-methoxy-ethyl]-carbamic acid tert-butyl ester

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Chemical Property of [(1S,2R)-2-((2S,3R)-1-Benzyl-3-benzyloxy-4-oxo-azetidin-2-yl)-1-(tert-butyl-diphenyl-silanyloxymethyl)-2-methoxy-ethyl]-carbamic acid tert-butyl ester

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Technology Process of [(1S,2R)-2-((2S,3R)-1-Benzyl-3-benzyloxy-4-oxo-azetidin-2-yl)-1-(tert-butyl-diphenyl-silanyloxymethyl)-2-methoxy-ethyl]-carbamic acid tert-butyl ester

There total 1 articles about [(1S,2R)-2-((2S,3R)-1-Benzyl-3-benzyloxy-4-oxo-azetidin-2-yl)-1-(tert-butyl-diphenyl-silanyloxymethyl)-2-methoxy-ethyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 19810-31-2
Benzyloxyacetyl chloride

: [(1S,2R)-3-[(E)-Benzylimino]-1-(tert-butyl-diphenyl-silanyloxymethyl)-2-methoxy-propyl]-carbamic acid tert-butyl ester

: 160527-49-1
[(1S,2R)-2-((2S,3R)-1-Benzyl-3-benzyloxy-4-oxo-azetidin-2-yl)-1-(tert-butyl-diphenyl-silanyloxymethyl)-2-methoxy-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: With triethylamine; In dichloromethane; for 20h; -78 degC -> r.t.;
DOI:10.1016/S0040-4039(00)77015-8

Reference yield: 95.0%

: 160527-49-1
[(1S,2R)-2-((2S,3R)-1-Benzyl-3-benzyloxy-4-oxo-azetidin-2-yl)-1-(tert-butyl-diphenyl-silanyloxymethyl)-2-methoxy-ethyl]-carbamic acid tert-butyl ester

: [(1S,2R)-2-((2R,3R)-1-Benzyl-3-hydroxy-4-oxo-azetidin-2-yl)-1-(tert-butyl-diphenyl-silanyloxymethyl)-2-methoxy-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: With ammonium formate; palladium on activated charcoal; In isopropyl alcohol; Heating;
DOI:10.1016/S0040-4039(00)77015-8

Reference yield:

: 160527-49-1
[(1S,2R)-2-((2S,3R)-1-Benzyl-3-benzyloxy-4-oxo-azetidin-2-yl)-1-(tert-butyl-diphenyl-silanyloxymethyl)-2-methoxy-ethyl]-carbamic acid tert-butyl ester

: (S)-4-[(R)-((S)-1-Benzyl-3,4-dioxo-azetidin-2-yl)-methoxy-methyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NBu₄F / 2.) 4-MeC₆H₄SO₃H / 1.) THF; 2.) C₆H₆, reflux

2: 90 percent / HCO₂NH₄ / Pd-C / propan-2-ol / Heating

3: P₂O₅ / dimethylsulfoxide / 16 h / Ambient temperature

With tetrabutyl ammonium fluoride; ammonium formate; phosphorus pentoxide; palladium on activated charcoal; toluene-4-sulfonic acid; In dimethyl sulfoxide; isopropyl alcohol;
DOI:10.1016/S0040-4039(00)77015-8